CIDeRplusGeneral Information:
| Id: | 7,522 |
| Diseases: |
Alzheimer disease
- [OMIM]
Metabolic |
| Mammalia | |
| review | |
| Reference: | Raber J(2008) AR, apoE, and cognitive function Horm Behav 53: 706-715 [PMID: 18395206] |
Interaction Information:
| Comment | At 6 months of age, apoE4 female showed impairments in hippocampus-dependent spatial learning and memory in the water maze. These impairments were observed in mice that express apoE4 in neurons or astrocytes and are therefore independent of the cellular source of apoE. They require apoE4 and are not seen in Apoe-/- female mice, consistent with a pathogenic gain of function of apoE4. |
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Formal Description Interaction-ID: 74174 |
gene/protein mutant decreases_activity of process spartial memory |
| Comment | At 6 months of age, apoE4 female showed impairments in hippocampus-dependent spatial learning and memory in the water maze. These impairments were observed in mice that express apoE4 in neurons or astrocytes and are therefore independent of the cellular source of apoE. They require apoE4 and are not seen in Apoe-/- female mice, consistent with a pathogenic gain of function of apoE4. |
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Formal Description Interaction-ID: 74176 |
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| Comment | Effects of apoE4 on AR function might contribute to these cognitive impairments. Treatment of 6-month apoE4 female mice with testosterone or dihydrotestosterone antagonized these impairments |
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Formal Description Interaction-ID: 74177 |
drug/chemical compound increases_activity of process spartial memory |
| Drugbank entries | Show/Hide entries for Testosterone |
| Comment | Effects of apoE4 on AR function might contribute to these cognitive impairments. Treatment of 6-month apoE4 female mice with testosterone or dihydrotestosterone antagonized these impairments |
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Formal Description Interaction-ID: 74181 |
drug/chemical compound increases_activity of process spartial memory |
| Drugbank entries | Show/Hide entries for Dihydrotestosterone |
| Comment | Compared to age-matched wild-type and Apoe‚ąí/‚ąí mice, expression of apoE4, but not apoE3, reduces cytosolic AR binding to androgens in the neocortex of female and male mice |
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Formal Description Interaction-ID: 74183 |
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| Drugbank entries | Show/Hide entries for Testosterone or AR |
| Comment | Compared to age-matched wild-type and Apoe-/- mice, expression of apoE4, but not apoE3, reduces cytosolic AR binding to androgens in the neocortex of female and male mice |
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Formal Description Interaction-ID: 74185 |
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| Drugbank entries | Show/Hide entries for AR |
| Comment | The mouse apoE colocalizes with AR in astrocytes. |
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Formal Description Interaction-ID: 74186 |
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| Drugbank entries | Show/Hide entries for APOE or AR |
| Comment | In cortical extracts, more AR was pulled down from extracts of NSE-apoE4 than NSE-apoE3 mice. GST-apoE proteins pull down ARs from cortical extracts of Apoe‚ąí/‚ąí mice and that GST-apoE4 might pull down more ARs than GST-apoE3 or GST-apoE2. |
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Formal Description Interaction-ID: 74188 |
gene/protein mutant interacts (colocalizes) with gene/protein |
| Drugbank entries | Show/Hide entries for AR |
| Comment | In cortical extracts, more AR was pulled down from extracts of NSE-apoE4 than NSE-apoE3 mice. GST-apoE proteins pull down ARs from cortical extracts of Apoe‚ąí/‚ąí mice and that GST-apoE4 might pull down more ARs than GST-apoE3 or GST-apoE2. |
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Formal Description Interaction-ID: 74189 |
gene/protein mutant interacts (colocalizes) with gene/protein |
| Drugbank entries | Show/Hide entries for AR |
| Comment | In cortical extracts, more AR was pulled down from extracts of NSE-apoE4 than NSE-apoE3 mice. GST-apoE proteins pull down ARs from cortical extracts of Apoe‚ąí/‚ąí mice and that GST-apoE4 might pull down more ARs than GST-apoE3 or GST-apoE2. |
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Formal Description Interaction-ID: 74190 |
gene/protein mutant interacts (colocalizes) with gene/protein |
| Drugbank entries | Show/Hide entries for AR |
| Comment | In the vertical limb of the diagonal band of Broca, a major cholinergic nucleus in the basal forebrain affected in AD, the presence of AD pathology or an őĶ4 allele negatively correlates with the percentage of AR-positive neurons in women, but not in men. |
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Formal Description Interaction-ID: 74192 |
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| Comment | In the vertical limb of the diagonal band of Broca, a major cholinergic nucleus in the basal forebrain affected in AD, the presence of AD pathology or an őĶ4 allele negatively correlates with the percentage of AR-positive neurons in women, but not in men. |
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Formal Description Interaction-ID: 74194 |
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| Comment | In the vertical limb of the diagonal band of Broca, a major cholinergic nucleus in the basal forebrain affected in AD, the presence of AD pathology or an őĶ4 allele negatively correlates with the percentage of AR-positive neurons in women, but not in men. |
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Formal Description Interaction-ID: 74196 |
gene/protein mutant decreases_quantity of tissue/cell line AR-positive neurons |
| Comment | In the vertical limb of the diagonal band of Broca, a major cholinergic nucleus in the basal forebrain affected in AD, the presence of AD pathology or an őĶ4 allele negatively correlates with the percentage of AR-positive neurons in women, but not in men. |
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Formal Description Interaction-ID: 74197 |
gene/protein mutant NOT affects_quantity of tissue/cell line AR-positive neurons |
| Comment | Altered AR function resulting from a polymorphism in the glutamine (CAG) repeats in exon 1 of the AR gene might increase AD risk; 20 or fewer CAG repeats are associated with increased AD risk in men, but not women, particularly in those lacking the E4 allele |
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Formal Description Interaction-ID: 74198 |
gene/protein mutant increases_activity of disease |
| Comment | As polymorphisms in the CAG repeats correlate with altered AR transcription and translation (the more CAGs the less active AR), these data indicate that enhanced AR function might be beneficial for E4, but not for non-E4 carriers. |
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Formal Description Interaction-ID: 74199 |
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| Drugbank entries | Show/Hide entries for AR |
| Comment | Altered AR function resulting from a polymorphism in the glutamine (CAG) repeats in exon 1 of the AR gene might increase AD risk; 20 or fewer CAG repeats are associated with increased AD risk in men, but not women, particularly in those lacking the E4 allele |
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Formal Description Interaction-ID: 74201 |
gene/protein mutant NOT affects_activity of disease |