CIDeRplusGeneral Information:
| Id: | 7,455 |
| Diseases: |
Metabolic
|
| Homo sapiens | |
| article | |
| Reference: | Nathan BP et al.(2004) Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons Endocrinology 145: 3065-3073 [PMID: 15033916] |
Interaction Information:
| Comment | Estradiol increased ApoE levels and neurite outgrowth. ApoE2 increased neurite length more so than ApoE3 in the presence of estradiol. |
|
Formal Description Interaction-ID: 73385 |
drug/chemical compound increases_expression of gene/protein mutant |
| Drugbank entries | Show/Hide entries for Estradiol |
| Comment | Estradiol increased ApoE levels and neurite outgrowth. ApoE2 increased neurite length more so than ApoE3 in the presence of estradiol. |
|
Formal Description Interaction-ID: 73392 |
gene/protein mutant increases_activity of process |
| Comment | Estradiol increased ApoE levels and neurite outgrowth. ApoE2 increased neurite length more so than ApoE3 in the presence of estradiol. |
|
Formal Description Interaction-ID: 73396 |
drug/chemical compound increases_expression of gene/protein mutant |
| Drugbank entries | Show/Hide entries for Estradiol |
| Comment | Estradiol increased ApoE levels and neurite outgrowth. ApoE2 increased neurite length more so than ApoE3 in the presence of estradiol. |
|
Formal Description Interaction-ID: 73397 |
gene/protein mutant increases_activity of process |
| Comment | Estradiol had no effect on neurite outgrowth from mice lacking the ApoE gene or when only ApoE4, the isoform of ApoE that is associated with increased risk of neurological disease, was exogenously supplied. |
|
Formal Description Interaction-ID: 73398 |
drug/chemical compound NOT affects_expression of gene/protein mutant |
| Drugbank entries | Show/Hide entries for Estradiol |
| Comment | Estradiol had no effect on neurite outgrowth from mice lacking the ApoE gene or when only ApoE4, the isoform of ApoE that is associated with increased risk of neurological disease, was exogenously supplied. |
|
Formal Description Interaction-ID: 73400 |
drug/chemical compound NOT affects_activity of process |
| Drugbank entries | Show/Hide entries for Estradiol |