General Information:

Id: 7,412
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
review
Reference: Riedel BC et al.(2016) Age, APOE and sex: Triad of risk of Alzheimers disease J. Steroid Biochem. Mol. Biol. 160: 134-147 [PMID: 26969397]

Interaction Information:

Comment Age, apolipoprotein E4 (APOE4) and chromosomal sex are well-established risk factors for late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least one APOE-E4 allele.
Formal Description
Interaction-ID: 72681

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Alzheimer disease

Comment The sex-based prevalence of AD is well documented with over 60% of persons with AD being female. Evidence indicates that the APOE-E4 risk for AD is greater in women than men, which is particularly evident in heterozygous women carrying one APOE-E4 allele. Paradoxically, men homozygous for APOE-E4 are reported to be at greater risk for mild cognitive impairment and AD.
Formal Description
Interaction-ID: 73892

phenotype

sex, female

increases_activity of

disease

Alzheimer disease

particularly in heterozygous women carrying one APOE-E4 allele;
Comment The sex-based prevalence of AD is well documented with over 60% of persons with AD being female. Evidence indicates that the APOE-E4 risk for AD is greater in women than men, which is particularly evident in heterozygous women carrying one APOE-E4 allele. Paradoxically, men homozygous for APOE-E4 are reported to be at greater risk for mild cognitive impairment and AD.
Formal Description
Interaction-ID: 73895

phenotype

sex, male

increases_activity of

disease

Alzheimer disease

particularly in men homozygous for APOE-E4;
Comment The sex-based prevalence of AD is well documented with over 60% of persons with AD being female. Evidence indicates that the APOE-E4 risk for AD is greater in women than men, which is particularly evident in heterozygous women carrying one APOE-E4 allele. Paradoxically, men homozygous for APOE-E4 are reported to be at greater risk for mild cognitive impairment and AD.
Formal Description
Interaction-ID: 73897

phenotype

sex, male

increases_activity of

phenotype

mild cognitive impairment

particularly in men homozygous for APOE-E4;