CIDeRplusGeneral Information:
| Id: | 7,368 |
| Diseases: |
Alzheimer disease
- [OMIM]
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| Homo sapiens | |
| BTO:0000142 brain | |
| article/cited | |
| Reference: | Hull J et al.(2015) Regional Increase in the Expression of the BCAT Proteins in Alzheimers Disease Brain: Implications in Glutamate Toxicity J. Alzheimers Dis. 45: 891-905 [PMID: 25633671] |
Interaction Information:
| Comment | Regional increase of hBCATc (BCAT1) expression was observed only in the CA1 region of the hippocampus in AD (Alzheimer's disease) brains relative to matched controls. All cases chosen had a postmortem (PM) delay of less than 15 h, had no significant comorbidities (such as vascular dementia or Parkinson’s disease) and were age- and gender-matched |
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Formal Description Interaction-ID: 72319 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for BCAT1 |
| Comment | The increased expression of hBCATm (BCAT2) in AD brain was observed in the CA1 and CA4 of the hippocampal region, in the temporal and frontal cortex. |
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Formal Description Interaction-ID: 72341 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for BCAT2 |
| Comment | The progression of Braak stage was correlated with increased density of hBCATm in frontal and temporal regions. |
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Formal Description Interaction-ID: 72342 |
phenotype increased level of BCAT2 cooccurs with phenotype Braak stage |
| Comment | The increasing of Braak stage was correlated with increased density of hBCATm in frontal and temporal regions. |
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Formal Description Interaction-ID: 72349 |
gene/protein increases_activity of phenotype Braak stage |
| Drugbank entries | Show/Hide entries for BCAT2 |
| Comment | hBCATm was highly S-glutathionylated in AD brains relative to matched controls. |
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Formal Description Interaction-ID: 72352 |
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| Comment | hBCATm was highly S-glutathionylated in AD brains relative to matched controls. |
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Formal Description Interaction-ID: 72355 |
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| Drugbank entries | Show/Hide entries for BCAT2 |
| Comment | In humans and rodents, hBCATc is predominantly found in the soma and proximal dendrites of glutamatergic and GABAergic neuronal cells, in keeping with its role in contributing to the storage and metabolic pools of glutamate, which is in turn decarboxylated in GABAergic neurons to formGABA[ |
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Formal Description Interaction-ID: 72594 |
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| Drugbank entries | Show/Hide entries for BCAT1 |
| Comment | In humans and rodents, hBCATc is predominantly found in the soma and proximal dendrites of glutamatergic and GABAergic neuronal cells, in keeping with its role in contributing to the storage and metabolic pools of glutamate, which is in turn decarboxylated in GABAergic neurons to formGABA[ |
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Formal Description Interaction-ID: 72596 |
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| Drugbank entries | Show/Hide entries for BCAT1 |
| Comment | In humans and rodents, hBCATc is predominantly found in the soma and proximal dendrites of glutamatergic and GABAergic neuronal cells, in keeping with its role in contributing to the storage and metabolic pools of glutamate, which is in turn decarboxylated in GABAergic neurons to form GABA. (cited) |
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Formal Description Interaction-ID: 72597 |
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| Comment | It was shown that hBCATm primarily is localized in astrocytes. (cited) |
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Formal Description Interaction-ID: 72599 |
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| Drugbank entries | Show/Hide entries for BCAT2 |
| Comment | Glutamate and GABA are involved in synaptic transmission. |
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Formal Description Interaction-ID: 72600 |
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| Comment | Glutamate and GABA are involved in synaptic transmission. |
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Formal Description Interaction-ID: 72601 |
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