General Information:

Id: 7,322 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Mielke MM et al.(2014) Clinical epidemiology of Alzheimers disease: assessing sex and gender differences Clin Epidemiol 6: 37-48 [PMID: 24470773]

Interaction Information:

Comment A large autopsy study found that amyloid plaque and neurofibrillary tangle pathology was greatest among women who were E4 carriers.
Formal Description
Interaction-ID: 71973

gene/protein mutant

APOE (isoform E4)

increases_quantity of

phenotype

neurofibrillary tangles

especially in APOE4 females / women