CIDeRplusGeneral Information:
| Id: | 7,322 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Mammalia | |
| review | |
| Reference: | Mielke MM et al.(2014) Clinical epidemiology of Alzheimers disease: assessing sex and gender differences Clin Epidemiol 6: 37-48 [PMID: 24470773] |
Interaction Information:
| Comment | The E4 allele of the apolipoprotein E (APOE) gene is the strongest known genetic risk factor for late-onset AD. Compared to non-carriers, heterozygous carriers of one E4 allele are 3‚Äď4 times more likely to develop AD, whereas the risk for homozygous carriers is even higher. The APOE E4 allele is specifically associated with an earlier age of onset of AD. |
|
Formal Description Interaction-ID: 71967 |
|
| Comment | The effects of the E4 genotype are more pronounced in women than in men. Three studies reported that women with one E4 allele had about a four-fold risk of AD, whereas men with one E4 allele showed little increased risk. |
|
Formal Description Interaction-ID: 71968 |
phenotype sex, female increases_activity of gene/protein mutant |
| Comment | The APOE E4 allele has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD. |
|
Formal Description Interaction-ID: 71969 |
gene/protein mutant decreases_activity of tissue/cell line |
| Comment | The APOE E4 allele has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD. |
|
Formal Description Interaction-ID: 71970 |
|
| Comment | The APOE E4 allele has a greater deleterious effect on hippocampal pathology, functional connectivity changes in the default mode network, cortical thickness, and memory performance in women compared with men at different stages of AD. |
|
Formal Description Interaction-ID: 71971 |
gene/protein mutant decreases_activity of process |
| Comment | A large autopsy study found that amyloid plaque and neurofibrillary tangle pathology was greatest among women who were E4 carriers. |
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Formal Description Interaction-ID: 71972 |
gene/protein mutant increases_quantity of phenotype |
| Comment | A large autopsy study found that amyloid plaque and neurofibrillary tangle pathology was greatest among women who were E4 carriers. |
|
Formal Description Interaction-ID: 71973 |
gene/protein mutant increases_quantity of phenotype |
| Comment | The effects of the E4 genotype are more pronounced in women than in men. Three studies reported that women with one E4 allele had about a four-fold risk of AD, whereas men with one E4 allele showed little increased risk. |
|
Formal Description Interaction-ID: 72092 |
gene/protein mutant increases_activity of disease |
| Comment | The effects of the E4 genotype are more pronounced in women than in men. Three studies reported that women with one E4 allele had about a four-fold risk of AD, whereas men with one E4 allele showed little increased risk. |
|
Formal Description Interaction-ID: 124712 |
phenotype sex, male decreases_activity of gene/protein mutant |