CIDeRplusGeneral Information:
| Id: | 7,308 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
Metabolic |
| Homo sapiens | |
| article/cited | |
| Reference: | Couttas TA et al.(2014) Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimers disease pathogenesis Acta Neuropathol Commun 2: 9 [PMID: 24456642] |
Interaction Information:
| Comment | Over 99% of AD cases are the age-related, late onset form of the disease, for which the greatest genetic risk factor is the APOE4 allele. Apolipoprotein E (ApoE) is a major lipid transport protein of the central nervous system (CNS) that also mediates the transport and clearance of Abeta. Homozygous carriers of the APOE4 allele have a 12-fold increased risk of developing AD, compared with non-carriers. (cited information) |
|
Formal Description Interaction-ID: 71708 |
|
| Comment | S1P/sphingosine ratio was 2.5-fold higher in hippocampus of ApoE2 carriers compared to ApoE4 carriers, and multivariate regression showed a significant association between APOE genotype and hippocampal S1P/sphingosine (p‚ÄČ=‚ÄČ0.0495), suggesting a new link between APOE genotype and pre-disposition to AD. |
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Formal Description Interaction-ID: 71716 |
gene/protein mutant decreases_activity of phenotype S1P/sphingosine ratio |