General Information:

Id: 7,288
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Dupuy AM et al.(2001) The relationship between apolipoprotein E4 and lipid metabolism is impaired in Alzheimers disease Gerontology 47: 213-218 [PMID: 11408727]

Interaction Information:

Comment ApoB levels were found to be higher in the presence of ApoE4, with no gender effect.
Formal Description
Interaction-ID: 71590

gene/protein mutant

APOE (isoform E4)

increases_quantity of

gene/protein

APOB

with no gender effect
Comment A significant association was observed between the E4 allele and AD only below age 80. In the control group, cholesterol levels were found to be significantly higher in men but not in women with an E4 allele (6.35 +/- 1.3 mmol/l) as opposed to those without (5.8 +/- 1.2 mmol/l).
Formal Description
Interaction-ID: 73921

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Alzheimer disease

only below age 80
Comment A significant association was observed between the E4 allele and AD only below age 80. In the control group, cholesterol levels were found to be significantly higher in men but not in women with an E4 allele (6.35 +/- 1.3 mmol/l) as opposed to those without (5.8 +/- 1.2 mmol/l).
Formal Description
Interaction-ID: 73922

process

aging

increases_activity of

gene/protein mutant

APOE (isoform E4)

only below age 80
Comment A significant association was observed between the E4 allele and AD only below age 80. In the control group, cholesterol levels were found to be significantly higher in men but not in women with an E4 allele (6.35 +/- 1.3 mmol/l) as opposed to those without (5.8 +/- 1.2 mmol/l).
Formal Description
Interaction-ID: 73923

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Cholesterol

in men
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