General Information:

Id: 7,255 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mammalia
review
Reference: Phillips MC(2014) Apolipoprotein E isoforms and lipoprotein metabolism IUBMB Life 66: 616-623 [PMID: 25328986]

Interaction Information:

Comment ApoE4 binds more to VLDL because of its higher lipid affinity leading to inhibition of lipolysis (probably because of displacement of apoC-II) so that, at the same apoE expression level of ApoE3 and ApoE4, progression down the lipolysis cascade is relatively limited in the case of apoE4.
Formal Description
Interaction-ID: 71448

gene/protein mutant

APOE (isoform E4)

decreases_activity of

process

lipid catabolic process

ApoE4 binds more to VLDL because of its higher lipid affinity leading to inhibition of lipolysis