General Information:

Id: 7,255 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mammalia
review
Reference: Phillips MC(2014) Apolipoprotein E isoforms and lipoprotein metabolism IUBMB Life 66: 616-623 [PMID: 25328986]

Interaction Information:

Comment In mice expressing either human apoE3 or apoE4 expression of apoE4 is associated with higher VLDL-cholesterol and incidence of atherosclerosis.
Formal Description
Interaction-ID: 71430

gene/protein mutant

APOE (isoform E4)

increases_activity of

phenotype

increased susceptibility to atherosclerosis

in transgenic mouse, in plasma