General Information:

Id: 7,250 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
HEK293 cells; ES-cell-derived human neurons
article
Reference: Huang YA et al.(2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 168: 427-441.e21 [PMID: 28111074]

Interaction Information:

Comment ApoE4 constitutes the most important genetic risk factor for Alzheimer’s disease (AD), ApoE3 is neutral, and ApoE2 is protective. The higher signaling efficacy of ApoE4 than ApoE3 in stimulating APP and Abeta synthesis may cause a cumulative effect over an individual’s lifetime, thus accounting for the increased Abeta concentrations and AD incidence in individuals expressing ApoE4.
Formal Description
Interaction-ID: 71364

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Alzheimer disease

if human neurons are cultured on mouse glia;