CIDeRplusGeneral Information:
| Id: | 7,250 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| HEK293 cells; ES-cell-derived human neurons | |
| article | |
| Reference: | Huang YA et al.(2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 168: 427-441.e21 [PMID: 28111074] |
Interaction Information:
| Comment | The three human ApoE isoforms increased DLK levels with the same differential potency as for the stimulation of Abeta synthesis and ERK1/2 phosphorylation (ApoE4>ApoE3>ApoE2). ApoE binding to ApoE receptors activates dual leucine-zipper kinase (DLK), a MAP-kinase kinase kinase that then activates MKK7 and ERK1/2 MAP kinases. Activated ERK1/2 induces cFos phosphorylation, stimulating the transcription factor AP-1, which in turn enhances transcription of amyloid-beta precursor protein (APP) and thereby increases amyloid-beta levels. This molecular mechanism also regulates APP transcription in mice in vivo. |
|
Formal Description Interaction-ID: 71334 |
gene/protein mutant increases_activity of gene/protein |