CIDeRplusGeneral Information:
| Id: | 7,250 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| HEK293 cells; ES-cell-derived human neurons | |
| article | |
| Reference: | Huang YA et al.(2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 168: 427-441.e21 [PMID: 28111074] |
Interaction Information:
| Comment | ApoE2, ApoE3, and ApoE4 differentially stimulate Abeta40 and Abeta42 secretion by human neurons cultured on MEFs (murine embryonic fibroblasts) with an ApoE4 > ApoE3 > ApoE2 potency rank order. |
|
Formal Description Interaction-ID: 71312 |
gene/protein mutant increases_activity of process Abeta (42) secretion |