CIDeRplusGeneral Information:
| Id: | 7,250 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| HEK293 cells; ES-cell-derived human neurons | |
| article | |
| Reference: | Huang YA et al.(2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 168: 427-441.e21 [PMID: 28111074] |
Interaction Information:
| Comment | All three ApoE isoforms robustly enhanced Abeta-synthesis, but with strikingly different efficacy (ApoE4>ApoE3>ApoE2). This differential efficacy was observed for total Abeta, Abeta40, or Abeta42, and for secreted as well as cellular Abeta, and was unrelated to alpha-or beta-secretase expression. |
|
Formal Description Interaction-ID: 124917 |
gene/protein mutant increases_quantity of gene/protein |