General Information:

Id: 7,238 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
plasma
article/cited
Reference: [PMID: 28035934]

Interaction Information:

Comment Women in the highest tertile of most sphingomyelins (except SM C20 : 1) had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship.
Formal Description
Interaction-ID: 71247

gene/protein mutant

APOE (isoform E4)

decreases_activity of

disease

Alzheimer disease

in plasma; among women, in the Baltimore Longitudinal Study of Aging;
Comment Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship.
Formal Description
Interaction-ID: 71259

phenotype

sex

affects_activity of

gene/protein mutant

APOE (isoform E4)

in plasma; concerning the risk of AD in the Baltimore Longitudinal Study of Aging;
Comment No significant interactions between ceramides and presence of an APOE (isoform E4) allele predicting risk of AD in either men or women were found.
Formal Description
Interaction-ID: 71262

gene/protein mutant

APOE (isoform E4)

NOT affects_activity of

drug/chemical compound

Ceramide

in plasma ; concerning the risk of AD among men and women in the Baltimore Longitudinal Study of Aging;
Comment There was no interaction found between sphingomyelin and the presence of an APOE (isoform E4) allele on AD risk among men.
Formal Description
Interaction-ID: 71264

gene/protein mutant

APOE (isoform E4)

NOT affects_activity of

drug/chemical compound

Sphingomyelin

in plasma; concerning the risk of AD among men in the Baltimore Longitudinal Study of Aging;