CIDeRplusGeneral Information:
| Id: | 7,238 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| plasma | |
| article/cited | |
| Reference: | [PMID: 28035934] |
Interaction Information:
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71259 |
phenotype sex affects_activity of gene/protein mutant |