CIDeRplusGeneral Information:
| Id: | 7,238 |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| plasma | |
| article/cited | |
| Reference: | [PMID: 28035934] |
Interaction Information:
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71212 |
drug/chemical compound Ceramide increases_activity of disease |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71213 |
drug/chemical compound increases_activity of disease |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71214 |
drug/chemical compound Ceramide NOT increases_activity of disease |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins (with the exception of C24 : 1) had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71215 |
drug/chemical compound decreases_activity of disease |
| Comment | Women in the highest tertile of most sphingomyelins (except SM C20 : 1) had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71247 |
gene/protein mutant decreases_activity of disease |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71257 |
phenotype sex, male affects_activity of drug/chemical compound Ceramide |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71258 |
phenotype sex affects_activity of drug/chemical compound |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship. |
|
Formal Description Interaction-ID: 71259 |
phenotype sex affects_activity of gene/protein mutant |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD in both univariate and multivariate analyses. The strongest association was with ceramide C16:0, which was associated with a greater than 2-fold increased risk of developing AD for the top tertile compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71260 |
drug/chemical compound Ceramide C16:0 increases_activity of disease |
| Comment | Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD in both univariate and multivariate analyses. The strongest association was with ceramide C16:0, which was associated with a greater than 2-fold increased risk of developing AD for the top tertile compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71261 |
phenotype sex, male affects_activity of drug/chemical compound Ceramide C16:0 |
| Comment | No significant interactions between ceramides and presence of an APOE (isoform E4) allele predicting risk of AD in either men or women were found. |
|
Formal Description Interaction-ID: 71262 |
gene/protein mutant NOT affects_activity of drug/chemical compound Ceramide |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71263 |
drug/chemical compound SM C18:0 increases_activity of disease |
| Comment | There was no interaction found between sphingomyelin and the presence of an APOE (isoform E4) allele on AD risk among men. |
|
Formal Description Interaction-ID: 71264 |
gene/protein mutant NOT affects_activity of drug/chemical compound |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71265 |
phenotype sex, male affects_activity of drug/chemical compound SM C18:0 |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71266 |
drug/chemical compound SM C18:1 increases_activity of disease |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71267 |
phenotype sex, male affects_activity of drug/chemical compound SM C18:1 |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71268 |
drug/chemical compound SM C20:1 increases_activity of disease |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71269 |
phenotype sex, male affects_activity of drug/chemical compound SM C20:1 |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71270 |
drug/chemical compound SM C22:1 increases_activity of disease |
| Comment | Among men, the middle tertile of sphingomyelin C18:0 and the highest tertile of sphingomyelins C18:1, C20:1, and C22:1 were associated with an increased risk of AD compared to the lowest tertile. |
|
Formal Description Interaction-ID: 71271 |
phenotype sex, male affects_activity of drug/chemical compound SM C22:1 |
| Comment | The highest, versus lowest, tertiles of sphingomyelins C16:0 and C22:1 were associated with a significantly reduced risk of AD among women. Most other sphingomyelins trended in the same direction. Across all sphingomyelins (except C20 : 1), women who were APOE E4 carriers and had sphingomyelin levels in either the middle or highest tertile, compared to the lowest, had reduced risks of AD. |
|
Formal Description Interaction-ID: 71273 |
drug/chemical compound SM C16:0 decreases_activity of disease |
| Comment | The highest, versus lowest, tertiles of sphingomyelins C16:0 and C22:1 were associated with a significantly reduced risk of AD among women. Most other sphingomyelins trended in the same direction. Across all sphingomyelins (except C20 : 1), women who were APOE E4 carriers and had sphingomyelin levels in either the middle or highest tertile, compared to the lowest, had reduced risks of AD. |
|
Formal Description Interaction-ID: 71274 |
drug/chemical compound SM C22:1 decreases_activity of disease |
| Comment | The highest, versus lowest, tertiles of sphingomyelins C16:0 and C22:1 were associated with a significantly reduced risk of AD among women. Most other sphingomyelins trended in the same direction. Across all sphingomyelins (except C20 : 1), women who were APOE E4 carriers and had sphingomyelin levels in either the middle or highest tertile, compared to the lowest, had reduced risks of AD. |
|
Formal Description Interaction-ID: 71275 |
phenotype sex, female affects_activity of drug/chemical compound SM C16:0 |
| Comment | Women who were APOE (isoform E4) carriers and had levels of sphingomyelin C24:0 in the middle or highest tertile, compared to the lowest tertile, had approximate 75% reduced risk of AD. |
|
Formal Description Interaction-ID: 71276 |
drug/chemical compound SM C24:0 decreases_activity of disease |
| Comment | Women who were APOE (isoform E4) carriers and had levels of sphingomyelin C24:0 in the middle or highest tertile, compared to the lowest tertile, had approximate 75% reduced risk of AD. |
|
Formal Description Interaction-ID: 71277 |
phenotype sex, female affects_activity of drug/chemical compound SM C24:0 |
| Comment | An autopsy study also reported disturbed sphingolipid metabolism among AD patients who were APOE E4 carriers. |
|
Formal Description Interaction-ID: 71278 |
disease decreases_activity of process |
| Comment | The highest, versus lowest, tertiles of sphingomyelins C16:0 and C22:1 were associated with a significantly reduced risk of AD among women. Most other sphingomyelins trended in the same direction. Across all sphingomyelins (except C20 : 1), women who were APOE E4 carriers and had sphingomyelin levels in either the middle or highest tertile, compared to the lowest, had reduced risks of AD. |
|
Formal Description Interaction-ID: 72091 |
phenotype sex, female affects_activity of drug/chemical compound SM C22:1 |