General Information:

Id: 72
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0001909 N1E-115 cell
article
Reference: Chadborn NH et al.(2006) PTEN couples Sema3A signalling to growth cone collapse. J. Cell. Sci. 119: 951-957 [PMID: 16495486]

Interaction Information:

Comment Expression of SEMA3A in neuroblastoma cells induces a decrease in the phosphorylation of glycogen synthase kinase 3 beta (GSK3beta) and Akt1.
Formal Description
Interaction-ID: 226

gene/protein

SEMA3A

decreases_phosphorylation of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Expression of SEMA3A in neuroblastoma cells induces a decrease in the phosphorylation of glycogen synthase kinase 3 beta (GSK3beta) and Akt1.
Formal Description
Interaction-ID: 227

gene/protein

SEMA3A

decreases_phosphorylation of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment Experiments indicate that PTEN is required for SEMA3A mediated dephosphorylation of glycogen synthase kinase 3 beta (GSK3beta) and Akt1.
Formal Description
Interaction-ID: 228

gene/protein

PTEN

affects_activity of

gene/protein

SEMA3A