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General Information:

Id:	718
Diseases:	Alzheimer disease - [OMIM]
Organism:	Mus musculus
Organism Model:	PDAPP (APPV717F) transgenic mouse
Tissue/Cell line:	brain
Publication type:	article
Reference:	Su Y et al.(2004) Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing Biochemistry 43: 6899-6908 [PMID: 15170327]

Interaction Information:

Comment	Lithium regulates amyloid-beta precursor protein (APP) processing.
Formal Description Interaction-ID: 4013	drug/chemical compound Lithium affects_processing of gene/protein APP
Drugbank entries	Show/Hide entries for Lithium or APP
Drugbank DB01356	Lithium inhibitor IMPA2
Drugbank DB01356	Lithium inhibitor IMPA1
Drugbank DB01356	Lithium inhibitor GSK3B
Drugbank DB01356	Lithium inhibitor INPP1
Drugbank DB01356	Lithium potentiator GRIA3
Drugbank DB02235	Methionine Sulfoxide not specified APP
Drugbank DB02235	Methionine Sulfoxide not specified APP

Comment	Valproic acid regulates amyloid-beta precursor protein (APP) processing.
Formal Description Interaction-ID: 4014	drug/chemical compound Valproic acid affects_processing of gene/protein APP
Drugbank entries	Show/Hide entries for Valproic acid or APP
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB
Drugbank DB02235	Methionine Sulfoxide not specified APP
Drugbank DB02235	Methionine Sulfoxide not specified APP

Comment	Lithium lowers the amyloid-beta (40, 42) peptide production.
Formal Description Interaction-ID: 4018	drug/chemical compound Lithium decreases_quantity of gene/protein Amyloid beta peptide (40)
Drugbank entries	Show/Hide entries for Lithium
Drugbank DB01356	Lithium inhibitor IMPA2
Drugbank DB01356	Lithium inhibitor IMPA1
Drugbank DB01356	Lithium inhibitor GSK3B
Drugbank DB01356	Lithium inhibitor INPP1
Drugbank DB01356	Lithium potentiator GRIA3

Comment	Valproic acid lowers the amyloid-beta (40,42) peptide production.
Formal Description Interaction-ID: 4019	drug/chemical compound Valproic acid decreases_quantity of gene/protein Amyloid beta peptide (40)
Drugbank entries	Show/Hide entries for Valproic acid
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB

Comment	GSK3beta is a potential downstream kinase and modulates APP processing.
Formal Description Interaction-ID: 4023	gene/protein GSK3B affects_processing of gene/protein APP
Drugbank entries	Show/Hide entries for GSK3B or APP
Drugbank DB01356	Lithium inhibitor GSK3B
Drugbank DB01772	3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl] ... not specified GSK3B
Drugbank DB01793	I-5 not specified GSK3B
Drugbank DB01950	N-(4-Methoxybenzyl)-N'-(5-Nitro-1,3-Thia ... not specified GSK3B
Drugbank DB02010	Staurosporine not specified GSK3B
Drugbank DB02052	Indirubin-3'-Monoxime not specified GSK3B
Drugbank DB03431	Adenosine-5'-Diphosphate not specified GSK3B
Drugbank DB03444	(3e)-6'-Bromo-2,3'-Biindole-2',3(1h,1'h) ... not specified GSK3B
Drugbank DB04014	Alsterpaullone not specified GSK3B
Drugbank DB04395	Phosphoaminophosphonic Acid-Adenylate Es ... not specified GSK3B
Drugbank DB07014	2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4- ... not specified GSK3B
Drugbank DB07058	5-[1-(4-methoxyphenyl)-1H-benzimidazol-6 ... not specified GSK3B
Drugbank DB07149	(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluo ... not specified GSK3B
Drugbank DB07584	N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phe ... not specified GSK3B
Drugbank DB07585	5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4 ... not specified GSK3B
Drugbank DB07676	3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)- ... not specified GSK3B
Drugbank DB07812	N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyr ... not specified GSK3B
Drugbank DB07859	4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL ... not specified GSK3B
Drugbank DB07947	ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CH ... not specified GSK3B
Drugbank DB08073	(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1 ... not specified GSK3B
Drugbank DB01772	3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl] ... not specified GSK3B
Drugbank DB01793	I-5 not specified GSK3B
Drugbank DB01950	N-(4-Methoxybenzyl)-N'-(5-Nitro-1,3-Thia ... not specified GSK3B
Drugbank DB02010	Staurosporine not specified GSK3B
Drugbank DB02052	Indirubin-3'-Monoxime not specified GSK3B
Drugbank DB03431	Adenosine-5'-Diphosphate not specified GSK3B
Drugbank DB04014	Alsterpaullone not specified GSK3B
Drugbank DB04395	Phosphoaminophosphonic Acid-Adenylate Es ... not specified GSK3B
Drugbank DB02235	Methionine Sulfoxide not specified APP
Drugbank DB02235	Methionine Sulfoxide not specified APP

Comment	Lithium treatment abolished GSK3beta- mediated Abeta increase in the brains of GSK3beta transgenics and reduced plaque burden in the brains of the PDAPP (APPV717F) transgenic mice.
Formal Description Interaction-ID: 4028	drug/chemical compound Lithium decreases_quantity of phenotype amyloid beta deposits in hippocampus
Drugbank entries	Show/Hide entries for Lithium
Drugbank DB01356	Lithium inhibitor IMPA2
Drugbank DB01356	Lithium inhibitor IMPA1
Drugbank DB01356	Lithium inhibitor GSK3B
Drugbank DB01356	Lithium inhibitor INPP1
Drugbank DB01356	Lithium potentiator GRIA3

Comment	Lithium lowers the amyloid-beta (40, 42) peptide production.
Formal Description Interaction-ID: 5839	drug/chemical compound Lithium decreases_quantity of gene/protein Amyloid beta peptide (42)
Drugbank entries	Show/Hide entries for Lithium
Drugbank DB01356	Lithium inhibitor IMPA2
Drugbank DB01356	Lithium inhibitor IMPA1
Drugbank DB01356	Lithium inhibitor GSK3B
Drugbank DB01356	Lithium inhibitor INPP1
Drugbank DB01356	Lithium potentiator GRIA3

Comment	Valproic acid lowers the amyloid-beta (40,42) peptide production.
Formal Description Interaction-ID: 5840	drug/chemical compound Valproic acid decreases_quantity of gene/protein Amyloid beta peptide (42)
Drugbank entries	Show/Hide entries for Valproic acid
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB