CIDeRplusGeneral Information:
| Id: | 6,894 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Salameh TS et al.(2016) Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimers disease Exp. Biol. Med. (Maywood) 241: 1676-1683 [PMID: 27470930] |
Interaction Information:
| Comment | The role that APOE plays in transport and clearance of molecules depends on the APOE isoform, and these transport differences may be related to differences in receptor utilization for the isoforms, with APOE4-Abeta complexes using the very low-density lipoprotein (VLDL) receptor and the other isoforms using LRP-1. These isoform specific differences may also affect how the blood-brain barrier (BBB) transports insulin, free fatty acids (FFAs), and other metabolites involved in cognitive processes. |
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Formal Description Interaction-ID: 67347 |
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