General Information:

Id: 672
Diseases: Status epilepticus
Rattus norvegicus
BTO: 0000601 hippocampus
article
Reference: Liu J et al.(2010) Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus Seizure 19: 165-172 [PMID: 20149694]

Interaction Information:

Comment The status epilepticus was induced in rats by lithium-pilocarpine administration.
Formal Description
Interaction-ID: 3592

drug/chemical compound

Pilocarpine

affects_activity of

disease

Status epilepticus

Drugbank entries Show/Hide entries for Pilocarpine
Comment The status epilepticus was induced in rats by lithium-pilocarpine administration.
Formal Description
Interaction-ID: 3593

drug/chemical compound

Lithium

affects_activity of

disease

Status epilepticus

Drugbank entries Show/Hide entries for Lithium
Comment The hippocampal neuron death occurs at 6h and is sustained for 7 days after status epilepticus.
Formal Description
Interaction-ID: 3594

disease

Status epilepticus

affects_activity of

process

neuron death

in lithium-pilocarpine model
Comment The expression of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and malondialdehyde (MDA) was increased after status epilepticus.
Formal Description
Interaction-ID: 3595

disease

Status epilepticus

increases_expression of

gene/protein

NOS1

in lithium-pilocarpine model
Drugbank entries Show/Hide entries for NOS1
Comment The expression of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and malondialdehyde (MDA) was increased after status epilepticus.
Formal Description
Interaction-ID: 3596

disease

Status epilepticus

increases_expression of

gene/protein

NOS2

in lithium-pilocarpine model
Drugbank entries Show/Hide entries for NOS2
Comment The expression of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and malondialdehyde (MDA) was increased after status epilepticus.
Formal Description
Interaction-ID: 3597

disease

Status epilepticus

increases_quantity of

drug/chemical compound

Malonaldehyde

in lithium-pilocarpine model
Drugbank entries Show/Hide entries for
Comment The production of nitric oxide (NO) started to increase at 30 min and was evident at 6h and 7 days after status epilepticus.
Formal Description
Interaction-ID: 3598

disease

Status epilepticus

increases_quantity of

drug/chemical compound

NO

in lithium-pilocarpine model
Comment The activated caspase-3 prominently appeared at 7 days after status epilepticus induced by lithium-pilocarpine.
Formal Description
Interaction-ID: 3728

disease

Status epilepticus

affects_activity of

gene/protein

CASP3

in lithium-pilocarpine model
Drugbank entries Show/Hide entries for CASP3
Comment The oxidative stress after onset of status epilepticus mediated hippocampal neuron death occurs prior to caspase-3 activation.
Formal Description
Interaction-ID: 3729

disease

Status epilepticus

affects_activity of

process

response to oxidative stress

in lithium-pilocarpine model
Comment The oxidative stress after onset of status epilepticus mediated hippocampal neuron death occurs prior to caspase-3 activation.
Formal Description
Interaction-ID: 3730

process

response to oxidative stress

affects_activity of

process

neuron death

in lithium-pilocarpine model