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Field	Query

	Field	Term

General Information:

Id:	670
Diseases:	Status epilepticus
Organism:	Rattus norvegicus
Organism Model:	Sprague-Dawley
Tissue/Cell line:	BTO: 0000601 hippocampus
Publication type:	article
Reference:	Wang HP et al.(2009) [Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion] Zhonghua Er Ke Za Zhi 47: 575-580 [PMID: 19951488]

Interaction Information:

Comment	The edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis.
Formal Description Interaction-ID: 3579	disease Status epilepticus increases_expression of gene/protein IL1B in lithium-pilocarpine model
Drugbank entries	Show/Hide entries for IL1B
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	The edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis.
Formal Description Interaction-ID: 3581	disease Status epilepticus increases_expression of gene/protein NFKB1 in lithium-pilocarpine model
Drugbank entries	Show/Hide entries for NFKB1
Drugbank DB01041	Thalidomide antagonist NFKB1
Drugbank DB01411	Pranlukast other/unknown NFKB1
Drugbank DB08814	Triflusal antagonist NFKB1

Comment	The edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis.
Formal Description Interaction-ID: 3584	drug/chemical compound Edaravone decreases_expression of gene/protein IL1B in lithium-pilocarpine model
Drugbank entries	Show/Hide entries for IL1B
Drugbank DB01017	Minocycline modulator IL1B
Drugbank DB05260	Gallium nitrate antagonist IL1B
Drugbank DB06168	Canakinumab not specified IL1B
Drugbank DB06168	Canakinumab not specified IL1B

Comment	The edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis.
Formal Description Interaction-ID: 3586	drug/chemical compound Edaravone decreases_expression of gene/protein NFKB1 in lithium-pilocarpine model
Drugbank entries	Show/Hide entries for NFKB1
Drugbank DB01041	Thalidomide antagonist NFKB1
Drugbank DB01411	Pranlukast other/unknown NFKB1
Drugbank DB08814	Triflusal antagonist NFKB1

Comment	The edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis.
Formal Description Interaction-ID: 3587	drug/chemical compound Edaravone decreases_activity of process neuron apoptotic process in lithium-pilocarpine model

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