General Information:

Id: 6,663 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Herzer S et al.(2015) Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase Diabetes 64: 3363-3376 [PMID: 26038579]

Interaction Information:

Comment The current study demonstrates that Ugcgf/f//CamKCreERT2 mice with genetic glucosylceramide synthase (GCS) deletion in forebrain neurons, dominantly targeting mediobasal hypothalamus (MBH), display impaired fasting-induced lipolysis accompanied by a decreased norepinephrine content in white adipose tissue (WAT). MBH insulin receptor (IR) levels and signaling are increased in Ugcgf/f//CamKCreERT2 mice.
Formal Description
Interaction-ID: 64521

gene/protein

UGCG

affects_quantity of

drug/chemical compound

Noradrenaline

Drugbank entries Show/Hide entries for UGCG