General Information:

Id: 6,481 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Folch J et al.(2015) The role of leptin in the sporadic form of Alzheimers disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin Life Sci. 140: 19-28 [PMID: 25998028]

Interaction Information:

Comment It has been shown that both the accumulation of Abeta and apoE4 genotype result in a transient enhancement of Lep signalling that might lead to Lep resistance over time. The mechanisms by which Abeta and apoE4 affect LepR expression are unknown.
Formal Description
Interaction-ID: 62475

gene/protein mutant

APOE (isoform E4)

increases_activity of

process

leptin-mediated signaling pathway

Accumulation of ApoE4 results in a transient enhancement of Lep signalling that might lead to Lep resistance over time.