General Information:

Id: 646 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0001976 Neuro-2a cell
article
Reference: Ezzi SA et al.(2007) Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation J. Neurochem. 102: 170-178 [PMID: 17394546]

Interaction Information:

Comment Oxidation affects the misfolding and aggregation of WT SOD1 as well as mutant SOD1 (G93A).
Formal Description
Interaction-ID: 3425

process

response to oxidative stress

increases_quantity of

phenotype

SOD1 protein aggregates

Comment Oxidized WT SOD1 can be conjugated to poly-ubiquitin. WT SOD1 in H2O2-treated cells was conjugated with multi-ubiquitin chain unlike WT SOD1 from untreated cells. The same phenomenon was observed with G93A mutant SOD1.
Formal Description
Interaction-ID: 3430

process

response to oxidative stress

increases_ubiquitination/sumoylation of

protein modification

SOD1-mod

Comment Oxidized WT SOD1 can be conjugated to poly-ubiquitin. WT SOD1 in H2O2-treated cells was conjugated with multi-ubiquitin chain unlike WT SOD1 from untreated cells. The same phenomenon was observed with G93A mutant SOD1.
Formal Description
Interaction-ID: 3431

process

response to oxidative stress

increases_ubiquitination/sumoylation of

gene/protein mutant

SOD1-p.G93A