CIDeRplusGeneral Information:
| Id: | 6,439 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type I
- [OMIM]
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Rattus norvegicus | |
| male | |
| streptozotocin-induced diabetic rat | |
| article | |
| Reference: | [PMID: 6162456] |
Interaction Information:
| Comment | Concentrations of polyamines, amino acids, glycogen, nucleic acids and protein, and activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase, were measured in livers from control, streptozotocin-diabetic and insulin-treated diabetic rats. Hepatic concentrations of the glucogenic amino acids, alanine, glutamine and glycine were decreased by diabetes. Their concentrations and that of glutamate were increased by injection of insulin. Concentrations of ornithine, proline, leucine, isoleucine and valine were increased in livers of diabetic rats and were decreased by insulin. Diabetes caused a decrease in hepatic concentration of serine, threonine, lysine and histidine. Insulin had no effect on serine, lysine and histidine, but caused a further fall in the concentration of threonine. |
|
Formal Description Interaction-ID: 60804 |
|
| Drugbank entries | Show/Hide entries for |