CIDeRplusGeneral Information:
| Id: | 6,438 |
| Diseases: |
Diabetes mellitus, type I
- [OMIM]
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Rattus norvegicus | |
| male | |
| streptozotocin-induced diabetic rat | |
| article | |
| Reference: | Bahmani F et al.(2012) Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats Mol. Vis. 18: 439-448 [PMID: 22355255] |
Interaction Information:
| Comment | The purpose of this paper was to investigate the effect of the oral administration of L-glycine (Gly) on the development of diabetic cataract induced by streptozotocin (STZ) in rats. Diabetic cataract gradually progressed in the STZ-administered group with no other treatment. Consequently, up to the end of the experiment, 2/3 of the animals in this group reached to the last stage of the cataract (mature cataract). The progress of this process was much slower in the diabetic group that was treated with Gly. |
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Formal Description Interaction-ID: 60778 |
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| Drugbank entries | Show/Hide entries for Streptozocin |
| Comment | The purpose of this paper was to investigate the effect of the oral administration of L-glycine (Gly) on the development of diabetic cataract induced by streptozotocin (STZ) in rats. Diabetic cataract gradually progressed in the STZ-administered group with no other treatment. Consequently, up to the end of the experiment, 2/3 of the animals in this group reached to the last stage of the cataract (mature cataract). The progress of this process was much slower in the diabetic group that was treated with Gly. |
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Formal Description Interaction-ID: 60779 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60780 |
disease Streptozocin-induced diabetes increases_activity of process protein glycation |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60781 |
disease Streptozocin-induced diabetes increases_quantity of drug/chemical compound Advanced glycation end-product |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60782 |
disease Streptozocin-induced diabetes increases_activity of gene/protein SOD |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60783 |
disease Streptozocin-induced diabetes increases_activity of gene/protein AKR1B |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60784 |
disease Streptozocin-induced diabetes decreases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60785 |
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| Drugbank entries | Show/Hide entries for CAT |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60786 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60787 |
drug/chemical compound decreases_quantity of drug/chemical compound Advanced glycation end-product |
| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60788 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60789 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity. |
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Formal Description Interaction-ID: 60790 |
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| Drugbank entries | Show/Hide entries for Glycine or Glutathione |
| Comment | The sorbitol dehydrogenase (SDH) activity in the lenses had no changes due to diabetes or treatment. |
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Formal Description Interaction-ID: 60791 |
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| Drugbank entries | Show/Hide entries for SORD |
| Comment | Glycine treatment significantly decreased the amount of serum glucose (Glc), serum AGEs, and glycated hemoglobin (HbA1c) in the diabetic rats. |
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Formal Description Interaction-ID: 60792 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Glycine treatment significantly decreased the amount of serum glucose (Glc), serum AGEs, and glycated hemoglobin (HbA1c) in the diabetic rats. |
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Formal Description Interaction-ID: 60793 |
drug/chemical compound decreases_quantity of drug/chemical compound Advanced glycation end-product |
| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Glycine treatment significantly decreased the amount of serum glucose (Glc), serum AGEs, and glycated hemoglobin (HbA1c) in the diabetic rats. |
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Formal Description Interaction-ID: 60794 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | Glycine treatment significantly decreased the amount of serum glucose (Glc), serum AGEs, and glycated hemoglobin (HbA1c) in the diabetic rats. |
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Formal Description Interaction-ID: 60795 |
drug/chemical compound decreases_activity of phenotype |
| Drugbank entries | Show/Hide entries for Glycine |
| Comment | The results indicated that the oral administration of Gly significantly delayed the onset and the progression of diabetic cataract in rats. These effects were due to its antiglycating action and to a lesser extent, due to the inhibition of oxidative stress and polyol pathway. |
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Formal Description Interaction-ID: 60796 |
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| Drugbank entries | Show/Hide entries for Glycine |
| Comment | The results indicated that the oral administration of Gly significantly delayed the onset and the progression of diabetic cataract in rats. These effects were due to its antiglycating action and to a lesser extent, due to the inhibition of oxidative stress and polyol pathway. |
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Formal Description Interaction-ID: 60797 |
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| Drugbank entries | Show/Hide entries for Glycine |