CIDeRplusGeneral Information:
| Id: | 6,436 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Kalapos MP(2013) Where does plasma methylglyoxal originate from? }, authors { names std { { name ml Kalapos MP, affil str Theoretical Biology Research Group, Budapest, Hungary. mpkalapos@freemail.hu } } }, from journal { title { iso-jta Diabetes Res. Clin. Pract Diabetes Res. Clin. Pract. 99: 260-271 [PMID: 23206674] |
Interaction Information:
| Comment | The elevation of plasma methylglyoxal levels in diabetic humans is widely observed. |
|
Formal Description Interaction-ID: 60767 |
disease increases_quantity of drug/chemical compound |
| Comment | D-Lactate concentration but not methylglyoxal concentration, correlated positively with HbA1c and blood glucose, supporting the view that plasma methylglyoxal is not related to glycolysis. |
|
Formal Description Interaction-ID: 60768 |
process NOT affects_quantity of drug/chemical compound |
| Comment | HbA1c levels detected in vivo, and methylglyoxal and D-lactate production in vitro did not correlate, whereas the rate of methylglyoxal formation and the cellular glyceraldehyde 3-phosphate dehydrogenase activity exhibited a strong negative correlation. The higher the enzymatic activity, the lower the level of methylglyoxal. This relationship was also seen between red blood cell glyceraldehyde 3-phosphate dehydrogenase activity and plasma methylglyoxal levels normalized to blood glucose in type 1 diabetic patients and in an NHS cohort study. |
|
Formal Description Interaction-ID: 60769 |
|
| Drugbank entries | Show/Hide entries for GAPDH |
| Comment | The metabolism of amino acids (mainly threonine and glycine, and partially tyrosine) is also connected with methylglyoxal formation. |
|
Formal Description Interaction-ID: 60775 |
|
| Comment | The metabolism of amino acids (mainly threonine and glycine, and partially tyrosine) is also connected with methylglyoxal formation. |
|
Formal Description Interaction-ID: 60776 |
|
| Drugbank entries | Show/Hide entries for Glycine |
| Comment | The metabolism of amino acids (mainly threonine and glycine, and partially tyrosine) is also connected with methylglyoxal formation. |
|
Formal Description Interaction-ID: 60777 |
|