CIDeRplusGeneral Information:
| Id: | 6,393 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Mutel E et al.(2011) Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon Diabetes 60: 3121-3131 [PMID: 22013018] |
Interaction Information:
| Comment | In mammals, sophisticated hormonal control by insulin, glucagon, glucocorticoids, and cathecholamines maintains blood glucose within narrow limits, orchestrating the uptake and production of glucose. In both the fed state and after 6 h fasting, glucagon levels were higher in L-G6pc-/- mice than in control mice. On the contrary, L-G6pc-/- mice exhibited a lower insulin level than that of control mice after 6 h fasting, but were not hypoinsulinemic in fed state. Corticosterone levels were markedly increased in L-G6pc-/- mice compared with the control mice after 6 h fasting, but not in the fed state. However, the epinephrine and norepinephrine plasma concentrations were similar in both L-G6pc-/- and control mice. This is in agreement with the observation that a hypoglycemic state around 60 mg/dL is mild and does not represent a stressed condition from the metabolic viewpoint, especially in the light of the concomitant increased availability of ketone bodies. |
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Formal Description Interaction-ID: 60570 |
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