General Information:

Id: 638
Diseases: Status epilepticus
Rattus norvegicus
Wistar
BTO:0000601 hippocampus; BTO:0000099 astrocyte; BTO:0000233 cerebral cortex
article
Reference: Naffah-Mazzacoratti MG et al.(1999) Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy Brain Res. Bull. 50: 229-239 [PMID: 10582521]

Interaction Information:

Comment The results showed decreased synthesis of heparan sulphate during the acute phase and an increased synthesis of chondroitin sulphate during the silent period in the cortex and hippocampus in pilocarpine-induced model of status epilepticus.
Formal Description
Interaction-ID: 3394

disease

Status epilepticus

decreases_quantity of

drug/chemical compound

Heparan sulfate

in acute phase of status epilepticus in pilocapine model
Comment The results showed decreased synthesis of heparan sulphate during the acute phase and an increased synthesis of chondroitin sulphate during the silent period in the cortex and hippocampus in pilocarpine-induced model of status epilepticus.
Formal Description
Interaction-ID: 3395

disease

Status epilepticus

decreases_quantity of

drug/chemical compound

Chondroitin sulfate

during silent period of status epilepticus in pilocapine model
Comment After 6 h of status epilepticus the RPTPbeta immunoreactivity was no longer detectable in the glial cells in both tissues and intense staining became evident in the matrix, surrounding CA3 and dentate gyrus and piriform cortex neurones. In the silent and chronic periods RPTPbeta immunoreactivity was mainly detected in neuronal somata and fibers of neurones of hippocampus and cortex.
Formal Description
Interaction-ID: 3396

disease

Status epilepticus

affects_activity of

gene/protein

PTPRZ1

in pilocarpine model of status epilepticus