General Information:

Id: 636
Diseases: Epilepsy, temporal lobe
Homo sapiens
BTO:0000601 hippocampus
article
Reference: Perosa SR et al.(2002) Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy. Brain Res. Bull. 58: 509-516 [PMID: 12242104]

Interaction Information:

Comment Compared to autopsy control tissue, epileptic hippocampi showed a significantly increased concentration of chondroitin sulfate (224%; p=0.0109) and hyaluronic acid (146%; p=0.039). The heparan sulfate was instead similar to control values.
Formal Description
Interaction-ID: 3388

disease

Epilepsy, temporal lobe

increases_quantity of

drug/chemical compound

Chondroitin sulfate

Comment Compared to autopsy control tissue, epileptic hippocampi showed a significantly increased concentration of chondroitin sulfate (224%; p=0.0109) and hyaluronic acid (146%; p=0.039). The heparan sulfate was instead similar to control values.
Formal Description
Interaction-ID: 3390

disease

Epilepsy, temporal lobe

increases_quantity of

drug/chemical compound

Hyaluronic acid

Comment Compared to autopsy control tissue, epileptic hippocampi showed a significantly increased concentration of chondroitin sulfate (224%; p=0.0109) and hyaluronic acid (146%; p=0.039). The heparan sulfate was instead similar to control values.
Formal Description
Interaction-ID: 3391

disease

Epilepsy, temporal lobe

NOT affects_quantity of

drug/chemical compound

Heparan sulfate

Comment RPTP zeta/beta immunoreactivity was induced in astrocytes of the inner molecular layer of the dentate gyrus of the sclerotic hippocampus.
Formal Description
Interaction-ID: 3393

disease

Epilepsy, temporal lobe

increases_expression of

gene/protein

PTPRZ1

in astrocytes