General Information:

Id: 6,356 (click here to show other Interactions for entry)
Diseases: Prostate cancer - [OMIM]
Homo sapiens
DU-145 prostate cancer cell
article
Reference: Makarevic J et al.(2014) Cross-communication between histone H3 and H4 acetylation and Akt-mTOR signalling in prostate cancer cells J. Cell. Mol. Med. 18: 1460-1466 [PMID: 24779401]

Interaction Information:

Comment DU-145 prostate cancer cells were treated with insulin-like growth factor (IGF) to activate the Akt-mTOR cascade or with the HDAC-inhibitor valproic acid (VPA) to induce histone H3 and H4 acetylation (aH3, aH4).
Formal Description
Interaction-ID: 59566

drug/chemical compound

Valproic acid

increases_activity of

process

histone H4 acetylation

in DU-145 prostata cancer cells
Drugbank entries Show/Hide entries for Valproic acid