General Information:

Id: 6,331
Diseases: Hepatocellular carcinoma - [OMIM]
Homo sapiens
article
Reference: Soll C et al.(2010) Serotonin promotes tumor growth in human hepatocellular cancer Hepatology 51: 1244-1254 [PMID: 20099302]

Interaction Information:

Comment Serotonin promotes tumor growth in human hepatocellular cancer.
Formal Description
Interaction-ID: 59395

drug/chemical compound

Serotonin

increases_activity of

phenotype

increased tumor growth/size

in Huh7 and HepG2 hepatocellular cancer cells
Comment During starvation hepatocellular carcinoma cells exhibited characteristics of autophagy, which disappeared in serotonin-treated cells.
Formal Description
Interaction-ID: 59396

process

response to starvation

increases_activity of

process

autophagy

in Huh7 and HepG2 hepatocellular cancer cells
Comment During starvation hepatocellular carcinoma cells exhibited characteristics of autophagy, which disappeared in serotonin-treated cells.
Formal Description
Interaction-ID: 59397

drug/chemical compound

Serotonin

decreases_activity of

process

autophagy

in Huh7 and HepG2 hepatocellular cancer cells; in response to starvation
Comment Human biopsies revealed expression of the serotonin receptor HTR2B, correlating with downstream signals, e.g., phosphorylated p70S6K and proliferation.
Formal Description
Interaction-ID: 59398

gene/protein

HTR2B

increases_activity of

gene/protein

RPS6KB1

Drugbank entries Show/Hide entries for HTR2B
Comment Human biopsies revealed expression of the serotonin receptor HTR2B, correlating with downstream signals, e.g., phosphorylated p70S6K and proliferation.
Formal Description
Interaction-ID: 59399

gene/protein

HTR2B

increases_activity of

process

cell population proliferation

Drugbank entries Show/Hide entries for HTR2B