CIDeRplusGeneral Information:
| Id: | 6,330 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Bennet H et al.(2015) Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes Peptides 71: 113-120 [PMID: 26206285] |
Interaction Information:
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59394 |
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| Drugbank entries | Show/Hide entries for HTR1A |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59466 |
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| Drugbank entries | Show/Hide entries for HTR1B |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59467 |
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| Drugbank entries | Show/Hide entries for HTR1D |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59468 |
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| Drugbank entries | Show/Hide entries for HTR1F |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59469 |
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| Drugbank entries | Show/Hide entries for HTR2A |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59470 |
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| Drugbank entries | Show/Hide entries for HTR2B |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59471 |
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| Drugbank entries | Show/Hide entries for HTR3A |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59472 |
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| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59473 |
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| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59474 |
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| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59475 |
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| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59476 |
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| Drugbank entries | Show/Hide entries for HTR4 |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59477 |
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| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59478 |
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| Drugbank entries | Show/Hide entries for HTR6 |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59479 |
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| Drugbank entries | Show/Hide entries for HTR7 |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59480 |
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| Drugbank entries | Show/Hide entries for TPH1 |
| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59481 |
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| Comment | The study shows the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. |
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Formal Description Interaction-ID: 59482 |
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| Drugbank entries | Show/Hide entries for DDC |
| Comment | Two 5-HT receptors (HTR1D and HTR2A) were over-expressed in T2D islet donors. Both receptors (5-HT1d and 5-HT2a) were localized to human alpha, beta and delta cells. |
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Formal Description Interaction-ID: 59483 |
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| Drugbank entries | Show/Hide entries for HTR1D |
| Comment | Two 5-HT receptors (HTR1D and HTR2A) were over-expressed in T2D islet donors. Both receptors (5-HT1d and 5-HT2a) were localized to human alpha, beta and delta cells. |
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Formal Description Interaction-ID: 59484 |
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| Drugbank entries | Show/Hide entries for HTR2A |
| Comment | 5-HT inhibited both insulin and glucagon secretion in non-diabetic islet donors. In islets isolated from T2D donors the amine significantly increased release of insulin in response to glucose. The results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non-diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D or arise as a consequence of an already dysfunctional islet. |
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Formal Description Interaction-ID: 59485 |
drug/chemical compound decreases_activity of process |
| Comment | 5-HT inhibited both insulin and glucagon secretion in non-diabetic islet donors. In islets isolated from T2D donors the amine significantly increased release of insulin in response to glucose. The results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non-diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D or arise as a consequence of an already dysfunctional islet. |
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Formal Description Interaction-ID: 59486 |
drug/chemical compound decreases_activity of process |
| Comment | 5-HT inhibited both insulin and glucagon secretion in non-diabetic islet donors. In islets isolated from T2D donors the amine significantly increased release of insulin in response to glucose. The results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non-diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D or arise as a consequence of an already dysfunctional islet. |
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Formal Description Interaction-ID: 59487 |
drug/chemical compound increases_activity of process |
| Comment | 5-HT is secreted from human islets of Langerhans in response to glucose. |
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Formal Description Interaction-ID: 59488 |
drug/chemical compound increases_activity of process |