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General Information:

Id:	6,295
Diseases:	Cancer
Organism:	Homo sapiens
Publication type:	article/cited
Reference:	[PMID: 24382387]

Interaction Information:

Comment	HDAC overexpression is not always a negative prognostic marker: Elevated HDAC6 levels predicted better prognosis in patients with estrogen receptor‚Äďpositive (ER-positive) breast cancer and correlated with improved prognosis in cutaneous T cell lymphoma (CTCL).
Formal Description Interaction-ID: 58956	gene/protein HDAC6 decreases_activity of disease Breast cancer if HDAC6 level is elevated, the prognosis is improved.
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	HDAC overexpression is not always a negative prognostic marker: Elevated HDAC6 levels predicted better prognosis in patients with estrogen receptor‚Äďpositive (ER-positive) breast cancer and correlated with improved prognosis in cutaneous T cell lymphoma (CTCL).
Formal Description Interaction-ID: 59036	gene/protein HDAC6 decreases_activity of disease Cutaneous T-cell lymphoma if HDAC6 level is elevated, the prognosis is improved.
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60523	gene/protein HDAC1 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60526	gene/protein HDAC1 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60532	gene/protein HDAC1 interacts (colocalizes) with gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC1 or HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60534	gene/protein HDAC2 interacts (colocalizes) with gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC2 or HDAC1
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60536	gene/protein HDAC3 interacts (colocalizes) with gene/protein HDAC4
Drugbank entries	Show/Hide entries for HDAC3 or HDAC4
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	HDAC8 (class I HDAC) is elevated in neuroblastoma cancer. KD reduced proliferation of lung, colon, and cervical cancer cells.
Formal Description Interaction-ID: 60544	disease Neuroblastoma increases_expression of gene/protein HDAC8
Drugbank entries	Show/Hide entries for HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8
Drugbank DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacet ... not specified HDAC8
Drugbank DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'- ... not specified HDAC8
Drugbank DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE not specified HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8

Comment	HDAC4 (class IIa HDAC) is associated with HDAC3-NCoR and GATA1. KD in chondrosarcoma cells increased VEGF expression and reduced growth and induced apoptosis of colon and glioblastoma tumors in vivo.
Formal Description Interaction-ID: 60547	gene/protein HDAC4 interacts (colocalizes) with gene/protein HDAC3-NCoR fusion protein
Drugbank entries	Show/Hide entries for HDAC4
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	HDAC5 (class IIa HDAC) is associated with HDAC3-NCoR, GATA1, and GATA2. It is elevated in medulloblastoma and decreased in lung cancer. KD decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60548	gene/protein HDAC5 interacts (colocalizes) with gene/protein HDAC3-NCoR fusion protein

Comment	HDAC7 (class IIa HDAC) is associated with HDAC3-NCoR and ERalpha. It is elevated in ALL (acute lymphoblastic leukemia) and decreased in lung cancer. KD induced growth arrest in colon and breast cancer cells.
Formal Description Interaction-ID: 60549	gene/protein HDAC7 interacts (colocalizes) with gene/protein HDAC3-NCoR fusion protein
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	HDAC9 (class IIa HDAC) is elevated in ALL (acute lymphoblastic leukemia) and medulloblastoma. KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60551	disease Leukemia, acute lymphoblastic increases_expression of gene/protein HDAC9
Drugbank entries	Show/Hide entries for HDAC9
Drugbank DB00313	Valproic Acid inhibitor HDAC9

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60552	gene/protein HDAC6 interacts (colocalizes) with gene/protein TUBA
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	In HDAC10 (class IIb HDAC) KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased VEGF expression.
Formal Description Interaction-ID: 60555	gene/protein HDAC10 increases_expression of gene/protein VEGFA test via knockdown experiments of HDAC9/HDAC10
Drugbank entries	Show/Hide entries for VEGFA
Drugbank DB00112	Bevacizumab not specified VEGFA
Drugbank DB01017	Minocycline inhibitor VEGFA
Drugbank DB01120	Gliclazide other/unknown VEGFA
Drugbank DB01136	Carvedilol other VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA
Drugbank DB06779	Dalteparin inhibitor VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA

Comment	HDAC11 (class IV HDAC) is associated with HDAC6. It is elevated in breast, renal, and liver cancer. KD induced apoptosis in colon, prostate, breast, and ovarian cancer cell lines.
Formal Description Interaction-ID: 60556	gene/protein HDAC11 interacts (colocalizes) with gene/protein HDAC6
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60588	gene/protein HDAC3 interacts (colocalizes) with gene/protein HDAC5
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60589	gene/protein HDAC3 interacts (colocalizes) with gene/protein HDAC7
Drugbank entries	Show/Hide entries for HDAC3 or HDAC7
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60590	gene/protein HDAC1 interacts (colocalizes) with gene/protein RCOR1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60591	gene/protein HDAC1 interacts (colocalizes) with complex/PPI NuRD complex via RbAp46/48 (=RBBP7/4)
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60592	gene/protein HDAC1 interacts (colocalizes) with gene/protein AML1-ETO fusion protein
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60593	gene/protein HDAC1 interacts (colocalizes) with complex/PPI SIN3 complex via RbAp46/48 (=RBBP7/4)
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60594	gene/protein HDAC1 interacts (colocalizes) with gene/protein PML
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60595	gene/protein HDAC1 interacts (colocalizes) with gene/protein ZBTB16
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60596	gene/protein HDAC1 interacts (colocalizes) with gene/protein BCL6
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60597	gene/protein HDAC1 interacts (colocalizes) with gene/protein TP53
Drugbank entries	Show/Hide entries for HDAC1 or TP53
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB08363	1-(9-ethyl-9H-carbazol-3-yl)-N-methylmet ... not specified TP53

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60598	disease Gastric cancer increases_expression of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60599	disease Breast cancer increases_expression of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60600	disease Colorectal cancer increases_expression of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60601	disease Lymphoma, Hodgkin, classic increases_expression of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60602	disease Lung cancer increases_expression of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60603	disease Hepatocellular carcinoma increases_expression of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60604	gene/protein HDAC1 decreases_activity of process cell quiescence in colon, breast, and osteosarcoma cancer cells; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60605	gene/protein HDAC1 increases_activity of process cell viability in colon, breast, and osteosarcoma cancer cells; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60606	gene/protein HDAC1 decreases_activity of process apoptotic process in colon, breast, and osteosarcoma cancer cells; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60607	gene/protein HDAC1 increases_activity of phenotype decreased survival rate of mice with overt PML-RAR alpha-mediated APL, tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60608	gene/protein HDAC2 interacts (colocalizes) with gene/protein RCOR1
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60609	gene/protein HDAC2 interacts (colocalizes) with complex/PPI NuRD complex via RbAp46/48 (=RBBP7/4)
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60610	gene/protein HDAC2 interacts (colocalizes) with complex/PPI SIN3 complex via RbAp46/48 (=RBBP7/4)
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60611	gene/protein HDAC2 interacts (colocalizes) with gene/protein AML1-ETO fusion protein
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60612	gene/protein HDAC2 interacts (colocalizes) with gene/protein PML
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60613	gene/protein HDAC2 interacts (colocalizes) with gene/protein ZBTB16
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60614	gene/protein HDAC2 interacts (colocalizes) with gene/protein BCL6
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60615	disease Gastric cancer increases_expression of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60616	disease Prostate cancer increases_expression of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60617	disease Colorectal cancer increases_expression of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60618	disease Lymphoma, Hodgkin, classic increases_expression of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60619	disease Cutaneous T-cell lymphoma increases_expression of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60620	gene/protein HDAC2 decreases_activity of process cell quiescence in colon and breast cancer cells; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60621	gene/protein HDAC2 increases_activity of process cell viability in colon and breast cancer cells; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60622	gene/protein HDAC2 decreases_activity of process apoptotic process in colon and breast cancer cells; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60623	gene/protein HDAC2 increases_activity of disease Lung cancer in vivo; accompanied by reduced apoptosis; tested via knockdown experiment.
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60624	gene/protein HDAC3 interacts (colocalizes) with gene/protein HDAC5
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60625	gene/protein HDAC3 interacts (colocalizes) with gene/protein HDAC7
Drugbank entries	Show/Hide entries for HDAC3 or HDAC7
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60626	gene/protein HDAC3 interacts (colocalizes) with gene/protein NCOR2
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60627	gene/protein HDAC3 interacts (colocalizes) with gene/protein AML1-ETO fusion protein
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60628	gene/protein HDAC3 interacts (colocalizes) with gene/protein PML
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60629	gene/protein HDAC3 interacts (colocalizes) with gene/protein ZBTB16
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60630	gene/protein HDAC3 interacts (colocalizes) with gene/protein PML-RARalpha fusion protein
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60631	gene/protein HDAC3 interacts (colocalizes) with gene/protein ZBTB16-RARalpha
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60632	gene/protein HDAC3 interacts (colocalizes) with gene/protein BCL6
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60633	gene/protein HDAC3 interacts (colocalizes) with gene/protein STAT1
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60634	gene/protein HDAC3 interacts (colocalizes) with gene/protein STAT3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60635	gene/protein HDAC3 interacts (colocalizes) with gene/protein STAT3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60636	gene/protein HDAC3 interacts (colocalizes) with gene/protein GATA1
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60637	gene/protein HDAC3 interacts (colocalizes) with gene/protein GATA2
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60639	gene/protein HDAC3 interacts (colocalizes) with complex/PPI NF-kappaB complex
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60641	disease Gastric cancer increases_expression of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60643	disease Breast cancer increases_expression of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60645	disease Leukemia, acute lymphoblastic increases_expression of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60646	disease Colorectal cancer increases_expression of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60647	disease Lymphoma, Hodgkin, classic increases_expression of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60651	disease Hepatocellular carcinoma decreases_expression of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60657	gene/protein HDAC3 affects_activity of phenotype altered survival rate
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60660	gene/protein HDAC3 decreases_activity of process apoptotic process
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with HDAC4, HDAC5, HDAC7, NCoR/SMRT, AML1-ETO, PML, PLZF, PML-RARalpha, PLZF-RARalpha, Bcl6, STAT1, STAT3, GATA1, GATA2, and NF-kappaB. It is elevated in gastric and breast cancer, ALL (acute lymphoblastic leukemia), colorectal cancer, and HL (Hodgkin lymphoma); decreased in liver cancer. KD in colon cancer cells decreased survival, increased apoptosis, and relieved transcriptional repression mediated by PML-RARalpha in APL cell.
Formal Description Interaction-ID: 60661	gene/protein HDAC3 affects_activity of process mRNA transcription in APL cell; mediated by PML-RARalpha
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC8 (class I HDAC) is elevated in neuroblastoma cancer. KD reduced proliferation of lung, colon, and cervical cancer cells.
Formal Description Interaction-ID: 60699	gene/protein HDAC8 increases_activity of disease Lung cancer in lung, colon, and cervical cancer cells; tested via knockdown experiment, concerning the cell proliferation.
Drugbank entries	Show/Hide entries for HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8
Drugbank DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacet ... not specified HDAC8
Drugbank DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'- ... not specified HDAC8
Drugbank DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE not specified HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8

Comment	HDAC8 (class I HDAC) is elevated in neuroblastoma cancer. KD reduced proliferation of lung, colon, and cervical cancer cells.
Formal Description Interaction-ID: 60700	gene/protein HDAC8 increases_activity of disease Colorectal cancer in lung, colon, and cervical cancer cells; tested via knockdown experiment, concerning the cell proliferation.
Drugbank entries	Show/Hide entries for HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8
Drugbank DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacet ... not specified HDAC8
Drugbank DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'- ... not specified HDAC8
Drugbank DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE not specified HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8

Comment	HDAC8 (class I HDAC) is elevated in neuroblastoma cancer. KD reduced proliferation of lung, colon, and cervical cancer cells.
Formal Description Interaction-ID: 60701	gene/protein HDAC8 increases_activity of disease Cervical cancer in lung, colon, and cervical cancer cells; tested via knockdown experiment, concerning the cell proliferation.
Drugbank entries	Show/Hide entries for HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8
Drugbank DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacet ... not specified HDAC8
Drugbank DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'- ... not specified HDAC8
Drugbank DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE not specified HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8

Comment	HDAC4 (class IIa HDAC) is associated with HDAC3-NCoR and GATA1. KD in chondrosarcoma cells increased VEGF expression and reduced growth and induced apoptosis of colon and glioblastoma tumors in vivo.
Formal Description Interaction-ID: 60702	gene/protein HDAC4 interacts (colocalizes) with gene/protein GATA1
Drugbank entries	Show/Hide entries for HDAC4
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	HDAC4 (class IIa HDAC) is associated with HDAC3-NCoR and GATA1. KD in chondrosarcoma cells increased VEGF expression and reduced growth and induced apoptosis of colon and glioblastoma tumors in vivo.
Formal Description Interaction-ID: 60703	gene/protein HDAC4 decreases_expression of gene/protein VEGFA in chondrosarcoma cells; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC4 or VEGFA
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4
Drugbank DB00112	Bevacizumab not specified VEGFA
Drugbank DB01017	Minocycline inhibitor VEGFA
Drugbank DB01120	Gliclazide other/unknown VEGFA
Drugbank DB01136	Carvedilol other VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA
Drugbank DB06779	Dalteparin inhibitor VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA

Comment	HDAC4 (class IIa HDAC) is associated with HDAC3-NCoR and GATA1. KD in chondrosarcoma cells increased VEGF expression and reduced growth and induced apoptosis of colon and glioblastoma tumors in vivo.
Formal Description Interaction-ID: 60704	gene/protein HDAC4 decreases_activity of process apoptotic process of colon and glioblastoma tumors in vivo; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC4
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	HDAC4 (class IIa HDAC) is associated with HDAC3-NCoR and GATA1. KD in chondrosarcoma cells increased VEGF expression and reduced growth and induced apoptosis of colon and glioblastoma tumors in vivo.
Formal Description Interaction-ID: 60705	gene/protein HDAC4 increases_activity of disease Colorectal cancer in vivo; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC4
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	HDAC4 (class IIa HDAC) is associated with HDAC3-NCoR and GATA1. KD in chondrosarcoma cells increased VEGF expression and reduced growth and induced apoptosis of colon and glioblastoma tumors in vivo.
Formal Description Interaction-ID: 60706	gene/protein HDAC4 increases_activity of disease Glioblastoma in vivo; tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC4
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	HDAC5 (class IIa HDAC) is associated with HDAC3-NCoR, GATA1, and GATA2. It is elevated in medulloblastoma and decreased in lung cancer. KD decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60707	gene/protein HDAC5 interacts (colocalizes) with gene/protein GATA1

Comment	HDAC5 (class IIa HDAC) is associated with HDAC3-NCoR, GATA1, and GATA2. It is elevated in medulloblastoma and decreased in lung cancer. KD decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60708	gene/protein HDAC5 interacts (colocalizes) with gene/protein GATA2

Comment	HDAC5 (class IIa HDAC) is associated with HDAC3-NCoR, GATA1, and GATA2. It is elevated in medulloblastoma and decreased in lung cancer. KD decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60709	disease Lung cancer decreases_expression of gene/protein HDAC5

Comment	HDAC5 (class IIa HDAC) is associated with HDAC3-NCoR, GATA1, and GATA2. It is elevated in medulloblastoma and decreased in lung cancer. KD decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60710	disease Medulloblastoma increases_expression of gene/protein HDAC5

Comment	HDAC5 (class IIa HDAC) is associated with HDAC3-NCoR, GATA1, and GATA2. It is elevated in medulloblastoma and decreased in lung cancer. KD decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60711	gene/protein HDAC5 increases_activity of disease Medulloblastoma tested via knockdown experiment, concerning cell growth and viability.

Comment	HDAC7 (class IIa HDAC) is associated with HDAC3-NCoR and ERalpha. It is elevated in ALL (acute lymphoblastic leukemia) and decreased in lung cancer. KD induced growth arrest in colon and breast cancer cells.
Formal Description Interaction-ID: 60712	gene/protein HDAC7 interacts (colocalizes) with gene/protein HDAC3-NCoR fusion protein
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60720	gene/protein HDAC1 interacts (colocalizes) with gene/protein AR
Drugbank entries	Show/Hide entries for HDAC1 or AR
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB00367	Levonorgestrel agonist AR
Drugbank DB00421	Spironolactone antagonist AR
Drugbank DB00499	Flutamide antagonist AR
Drugbank DB00621	Oxandrolone agonist AR
Drugbank DB00624	Testosterone agonist AR
Drugbank DB00665	Nilutamide antagonist AR
Drugbank DB00687	Fludrocortisone agonist AR
Drugbank DB00858	Dromostanolone agonist AR
Drugbank DB00984	Nandrolone phenpropionate agonist AR
Drugbank DB01128	Bicalutamide antagonist AR
Drugbank DB01185	Fluoxymesterone agonist AR
Drugbank DB01395	Drospirenone antagonist AR
Drugbank DB01406	Danazol agonist AR
Drugbank DB01420	Testosterone Propionate agonist AR
Drugbank DB01481	Delta1-dihydrotestosterone agonist AR
Drugbank DB01541	Boldenone agonist AR
Drugbank DB01564	Calusterone not specified AR
Drugbank DB02266	Flufenamic Acid not specified AR
Drugbank DB02901	Dihydrotestosterone not specified AR
Drugbank DB02932	(2r)-N-[4-Cyano-3-(Trifluoromethyl)Pheny ... not specified AR
Drugbank DB02998	Methyltrienolone not specified AR
Drugbank DB04709	(3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7, ... not specified AR
Drugbank DB04839	Cyproterone antagonist AR
Drugbank DB06710	Methyltestosterone agonist AR
Drugbank DB06870	17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGN ... not specified AR
Drugbank DB07039	(2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyano ... not specified AR
Drugbank DB07286	2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXO ... not specified AR
Drugbank DB07419	(2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-c ... not specified AR
Drugbank DB07421	4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4- ... not specified AR
Drugbank DB07422	(2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(tr ... not specified AR
Drugbank DB07423	(2S)-3-[4-(acetylamino)phenoxy]-2-hydrox ... not specified AR
Drugbank DB07454	(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITR ... not specified AR
Drugbank DB07717	(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-D ... not specified AR
Drugbank DB07769	S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL ... not specified AR
Drugbank DB08035	1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-P ... not specified AR
Drugbank DB08087	4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDR ... not specified AR
Drugbank DB08088	2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1- ... not specified AR
Drugbank DB08089	6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TR ... not specified AR
Drugbank DB08461	3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4 ... not specified AR
Drugbank DB08804	Nandrolone decanoate agonist AR
Drugbank DB00499	Flutamide antagonist AR
Drugbank DB00621	Oxandrolone agonist AR
Drugbank DB00624	Testosterone agonist AR
Drugbank DB00665	Nilutamide antagonist AR
Drugbank DB00858	Drostanolone agonist AR
Drugbank DB00984	Nandrolone phenpropionate agonist AR
Drugbank DB01481	Delta1-dihydrotestosterone agonist AR
Drugbank DB01541	Boldenone agonist AR
Drugbank DB01564	Calusterone not specified AR
Drugbank DB02901	Dihydrotestosterone not specified AR
Drugbank DB04839	Cyproterone antagonist AR

Comment	HDAC7 (class IIa HDAC) is associated with HDAC3-NCoR and ERalpha. It is elevated in ALL (acute lymphoblastic leukemia) and decreased in lung cancer. KD induced growth arrest in colon and breast cancer cells.
Formal Description Interaction-ID: 60721	gene/protein HDAC7 interacts (colocalizes) with gene/protein ESR1
Drugbank entries	Show/Hide entries for HDAC7 or ESR1
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7
Drugbank DB00255	Diethylstilbestrol agonist ESR1
Drugbank DB00269	Chlorotrianisene agonist ESR1
Drugbank DB00286	Conjugated Estrogens agonist ESR1
Drugbank DB00294	Etonogestrel agonist ESR1
Drugbank DB00304	Desogestrel agonist ESR1
Drugbank DB00367	Levonorgestrel other ESR1
Drugbank DB00396	Progesterone agonist ESR1
Drugbank DB00481	Raloxifene agonist ESR1
Drugbank DB00506	Norgestrel agonist ESR1
Drugbank DB00539	Toremifene modulator ESR1
Drugbank DB00603	Medroxyprogesterone agonist ESR1
Drugbank DB00655	Estrone agonist ESR1
Drugbank DB00675	Tamoxifen antagonist ESR1
Drugbank DB00783	Estradiol agonist ESR1
Drugbank DB00823	Ethynodiol Diacetate agonist ESR1
Drugbank DB00882	Clomifene antagonist ESR1
Drugbank DB00890	Dienestrol agonist ESR1
Drugbank DB00947	Fulvestrant antagonist ESR1
Drugbank DB00957	Norgestimate agonist ESR1
Drugbank DB00977	Ethinyl Estradiol agonist ESR1
Drugbank DB01065	Melatonin antagonist ESR1
Drugbank DB01108	Trilostane allosteric modulator ESR1
Drugbank DB01183	Naloxone other/unknown ESR1
Drugbank DB01185	Fluoxymesterone antagonist ESR1
Drugbank DB01196	Estramustine agonist ESR1
Drugbank DB01357	Mestranol agonist ESR1
Drugbank DB01406	Danazol agonist ESR1
Drugbank DB01431	Allylestrenol agonist ESR1
Drugbank DB01645	Genistein not specified ESR1
Drugbank DB02615	Compound 19 not specified ESR1
Drugbank DB02715	Compound 18 not specified ESR1
Drugbank DB03742	Compound 4-D not specified ESR1
Drugbank DB03802	1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Y ... not specified ESR1
Drugbank DB04471	2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)- ... not specified ESR1
Drugbank DB04573	Estriol agonist ESR1
Drugbank DB04574	Estropipate agonist ESR1
Drugbank DB04575	Quinestrol agonist ESR1
Drugbank DB06713	Norelgestromin agonist ESR1
Drugbank DB06871	17-METHYL-17-ALPHA-DIHYDROEQUILENIN not specified ESR1
Drugbank DB06898	4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyr ... not specified ESR1
Drugbank DB06927	[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFU ... not specified ESR1
Drugbank DB07086	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL ... not specified ESR1
Drugbank DB07087	4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-D ... not specified ESR1
Drugbank DB07195	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TR ... not specified ESR1
Drugbank DB07567	(2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL- ... not specified ESR1
Drugbank DB07638	(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPH ... not specified ESR1
Drugbank DB07678	(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN- ... not specified ESR1
Drugbank DB07707	(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-1 ... not specified ESR1
Drugbank DB07708	3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL- ... not specified ESR1
Drugbank DB07712	3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5 ... not specified ESR1
Drugbank DB07932	dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl ... not specified ESR1
Drugbank DB07933	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3 ... not specified ESR1
Drugbank DB07991	N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROP ... not specified ESR1
Drugbank DB08020	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METH ... not specified ESR1
Drugbank DB08047	4-[1-allyl-7-(trifluoromethyl)-1H-indazo ... not specified ESR1
Drugbank DB08048	4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3 ... not specified ESR1
Drugbank DB08320	DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYP ... not specified ESR1
Drugbank DB08398	2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]P ... not specified ESR1
Drugbank DB08595	4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYC ... not specified ESR1
Drugbank DB08737	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3 ... not specified ESR1
Drugbank DB08773	RALOXIFENE CORE not specified ESR1
Drugbank DB00255	Diethylstilbestrol agonist ESR1
Drugbank DB00269	Chlorotrianisene agonist ESR1
Drugbank DB00286	Conjugated Estrogens agonist ESR1
Drugbank DB00294	Etonogestrel agonist ESR1
Drugbank DB00481	Raloxifene agonist ESR1
Drugbank DB00539	Toremifene modulator ESR1
Drugbank DB00655	Estrone agonist ESR1
Drugbank DB00882	Clomifene antagonist ESR1
Drugbank DB00890	Dienestrol agonist ESR1
Drugbank DB00947	Fulvestrant antagonist ESR1
Drugbank DB00957	Norgestimate agonist ESR1
Drugbank DB00977	Ethinyl Estradiol agonist ESR1
Drugbank DB01196	Estramustine agonist ESR1
Drugbank DB01357	Mestranol agonist ESR1
Drugbank DB02615	Compound 19 not specified ESR1
Drugbank DB02715	Compound 18 not specified ESR1
Drugbank DB03742	Compound 4-D not specified ESR1
Drugbank DB03802	1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Y ... not specified ESR1
Drugbank DB04471	2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)- ... not specified ESR1
Drugbank DB04573	Estriol agonist ESR1
Drugbank DB04575	Quinestrol agonist ESR1

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60722	gene/protein HDAC1 interacts (colocalizes) with gene/protein ESR1
Drugbank entries	Show/Hide entries for HDAC1 or ESR1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB00255	Diethylstilbestrol agonist ESR1
Drugbank DB00269	Chlorotrianisene agonist ESR1
Drugbank DB00286	Conjugated Estrogens agonist ESR1
Drugbank DB00294	Etonogestrel agonist ESR1
Drugbank DB00304	Desogestrel agonist ESR1
Drugbank DB00367	Levonorgestrel other ESR1
Drugbank DB00396	Progesterone agonist ESR1
Drugbank DB00481	Raloxifene agonist ESR1
Drugbank DB00506	Norgestrel agonist ESR1
Drugbank DB00539	Toremifene modulator ESR1
Drugbank DB00603	Medroxyprogesterone agonist ESR1
Drugbank DB00655	Estrone agonist ESR1
Drugbank DB00675	Tamoxifen antagonist ESR1
Drugbank DB00783	Estradiol agonist ESR1
Drugbank DB00823	Ethynodiol Diacetate agonist ESR1
Drugbank DB00882	Clomifene antagonist ESR1
Drugbank DB00890	Dienestrol agonist ESR1
Drugbank DB00947	Fulvestrant antagonist ESR1
Drugbank DB00957	Norgestimate agonist ESR1
Drugbank DB00977	Ethinyl Estradiol agonist ESR1
Drugbank DB01065	Melatonin antagonist ESR1
Drugbank DB01108	Trilostane allosteric modulator ESR1
Drugbank DB01183	Naloxone other/unknown ESR1
Drugbank DB01185	Fluoxymesterone antagonist ESR1
Drugbank DB01196	Estramustine agonist ESR1
Drugbank DB01357	Mestranol agonist ESR1
Drugbank DB01406	Danazol agonist ESR1
Drugbank DB01431	Allylestrenol agonist ESR1
Drugbank DB01645	Genistein not specified ESR1
Drugbank DB02615	Compound 19 not specified ESR1
Drugbank DB02715	Compound 18 not specified ESR1
Drugbank DB03742	Compound 4-D not specified ESR1
Drugbank DB03802	1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Y ... not specified ESR1
Drugbank DB04471	2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)- ... not specified ESR1
Drugbank DB04573	Estriol agonist ESR1
Drugbank DB04574	Estropipate agonist ESR1
Drugbank DB04575	Quinestrol agonist ESR1
Drugbank DB06713	Norelgestromin agonist ESR1
Drugbank DB06871	17-METHYL-17-ALPHA-DIHYDROEQUILENIN not specified ESR1
Drugbank DB06898	4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyr ... not specified ESR1
Drugbank DB06927	[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFU ... not specified ESR1
Drugbank DB07086	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL ... not specified ESR1
Drugbank DB07087	4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-D ... not specified ESR1
Drugbank DB07195	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TR ... not specified ESR1
Drugbank DB07567	(2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL- ... not specified ESR1
Drugbank DB07638	(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPH ... not specified ESR1
Drugbank DB07678	(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN- ... not specified ESR1
Drugbank DB07707	(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-1 ... not specified ESR1
Drugbank DB07708	3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL- ... not specified ESR1
Drugbank DB07712	3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5 ... not specified ESR1
Drugbank DB07932	dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl ... not specified ESR1
Drugbank DB07933	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3 ... not specified ESR1
Drugbank DB07991	N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROP ... not specified ESR1
Drugbank DB08020	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METH ... not specified ESR1
Drugbank DB08047	4-[1-allyl-7-(trifluoromethyl)-1H-indazo ... not specified ESR1
Drugbank DB08048	4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3 ... not specified ESR1
Drugbank DB08320	DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYP ... not specified ESR1
Drugbank DB08398	2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]P ... not specified ESR1
Drugbank DB08595	4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYC ... not specified ESR1
Drugbank DB08737	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3 ... not specified ESR1
Drugbank DB08773	RALOXIFENE CORE not specified ESR1
Drugbank DB00255	Diethylstilbestrol agonist ESR1
Drugbank DB00269	Chlorotrianisene agonist ESR1
Drugbank DB00286	Conjugated Estrogens agonist ESR1
Drugbank DB00294	Etonogestrel agonist ESR1
Drugbank DB00481	Raloxifene agonist ESR1
Drugbank DB00539	Toremifene modulator ESR1
Drugbank DB00655	Estrone agonist ESR1
Drugbank DB00882	Clomifene antagonist ESR1
Drugbank DB00890	Dienestrol agonist ESR1
Drugbank DB00947	Fulvestrant antagonist ESR1
Drugbank DB00957	Norgestimate agonist ESR1
Drugbank DB00977	Ethinyl Estradiol agonist ESR1
Drugbank DB01196	Estramustine agonist ESR1
Drugbank DB01357	Mestranol agonist ESR1
Drugbank DB02615	Compound 19 not specified ESR1
Drugbank DB02715	Compound 18 not specified ESR1
Drugbank DB03742	Compound 4-D not specified ESR1
Drugbank DB03802	1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Y ... not specified ESR1
Drugbank DB04471	2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)- ... not specified ESR1
Drugbank DB04573	Estriol agonist ESR1
Drugbank DB04575	Quinestrol agonist ESR1

Comment	HDAC7 (class IIa HDAC) is associated with HDAC3-NCoR and ERalpha. It is elevated in ALL (acute lymphoblastic leukemia) and decreased in lung cancer. KD induced growth arrest in colon and breast cancer cells.
Formal Description Interaction-ID: 60723	disease Leukemia, acute lymphoblastic increases_expression of gene/protein HDAC7
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	HDAC7 (class IIa HDAC) is associated with HDAC3-NCoR and ERalpha. It is elevated in ALL (acute lymphoblastic leukemia) and decreased in lung cancer. KD induced growth arrest in colon and breast cancer cells.
Formal Description Interaction-ID: 60724	disease Lung cancer decreases_expression of gene/protein HDAC7
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	HDAC7 (class IIa HDAC) is associated with HDAC3-NCoR and ERalpha. It is elevated in ALL (acute lymphoblastic leukemia) and decreased in lung cancer. KD induced growth arrest in colon and breast cancer cells.
Formal Description Interaction-ID: 60725	gene/protein HDAC7 increases_activity of disease Colorectal cancer tested via knockdown experiment, concerning growth arrest in colon and breast cancer cells
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	HDAC7 (class IIa HDAC) is associated with HDAC3-NCoR and ERalpha. It is elevated in ALL (acute lymphoblastic leukemia) and decreased in lung cancer. KD induced growth arrest in colon and breast cancer cells.
Formal Description Interaction-ID: 60726	gene/protein HDAC7 increases_activity of disease Breast cancer tested via knockdown experiment, concerning growth arrest in colon and breast cancer cells
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60727	gene/protein HDAC2 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60728	gene/protein HDAC2 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60729	gene/protein HDAC3 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60730	gene/protein HDAC4 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC4
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60731	gene/protein HDAC5 affects_activity of process gene expression

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60732	gene/protein HDAC3 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60733	gene/protein HDAC4 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC4
Drugbank DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidaz ... not specified HDAC4
Drugbank DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHY ... not specified HDAC4

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60734	gene/protein HDAC5 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60735	gene/protein HDAC6 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60736	gene/protein HDAC7 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60737	gene/protein HDAC8 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8
Drugbank DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacet ... not specified HDAC8
Drugbank DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'- ... not specified HDAC8
Drugbank DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE not specified HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60738	gene/protein HDAC9 affects_activity of process gene expression
Drugbank entries	Show/Hide entries for HDAC9
Drugbank DB00313	Valproic Acid inhibitor HDAC9

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60739	gene/protein HDAC10 affects_activity of process gene expression

Comment	Histone acetylation is an important determinant of gene expression. Acetylation is generally associated with elevated transcription, while deacetylated histones are often associated with gene repression. Histone deacetylases (HDACs) are critical regulators of gene expression that enzymatically remove the acetyl group from histones.
Formal Description Interaction-ID: 60740	gene/protein HDAC11 affects_activity of process gene expression

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60741	gene/protein HDAC6 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60742	gene/protein HDAC7 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC7
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC7

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60743	gene/protein HDAC8 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8
Drugbank DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacet ... not specified HDAC8
Drugbank DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'- ... not specified HDAC8
Drugbank DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE not specified HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60744	gene/protein HDAC9 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.
Drugbank entries	Show/Hide entries for HDAC9
Drugbank DB00313	Valproic Acid inhibitor HDAC9

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60745	gene/protein HDAC10 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.

Comment	A broader role for HDACs as acyl-lysine ‚Äúerasers‚ÄĚ is also emerging with the discovery of additional acyl-lysine histone modifications such as crotonylation, succinylation, and malonylation.
Formal Description Interaction-ID: 60746	gene/protein HDAC11 affects_activity of process histone modification such as crotonylation, succinylation, and malonylation.

Comment	HDAC9 (class IIa HDAC) is elevated in ALL (acute lymphoblastic leukemia) and medulloblastoma. KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased medullablastoma cell growth and viability.
Formal Description Interaction-ID: 60747	disease Medulloblastoma increases_expression of gene/protein HDAC9
Drugbank entries	Show/Hide entries for HDAC9
Drugbank DB00313	Valproic Acid inhibitor HDAC9

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60748	gene/protein HDAC6 interacts (colocalizes) with gene/protein HSP90
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60749	gene/protein HDAC6 interacts (colocalizes) with gene/protein HDAC11
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60750	disease Breast cancer increases_expression of gene/protein HDAC6
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60751	disease Cutaneous T-cell lymphoma increases_expression of gene/protein HDAC6
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60752	disease Lung cancer decreases_expression of gene/protein HDAC6
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60753	gene/protein HDAC6 increases_expression of gene/protein VEGFA tested via knockdown experiment
Drugbank entries	Show/Hide entries for HDAC6 or VEGFA
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB00112	Bevacizumab not specified VEGFA
Drugbank DB01017	Minocycline inhibitor VEGFA
Drugbank DB01120	Gliclazide other/unknown VEGFA
Drugbank DB01136	Carvedilol other VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA
Drugbank DB06779	Dalteparin inhibitor VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA

Comment	HDAC6 (class IIb HDAC) is associated with alpha-Tubulin, HSP90, and HDAC11. It is elevated in breast cancer and CTCL (cutaneous T cell lymphoma) and decreased in lung cancer. KD decreased VEGF expression and decreased cell viability due to accumulation of misfolded proteins.
Formal Description Interaction-ID: 60754	gene/protein HDAC6 increases_activity of process cell viability tested via knockdown experiment, concerning cell viability due to accumulation of misfolded proteins
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	In HDAC10 (class IIb HDAC) KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased VEGF expression.
Formal Description Interaction-ID: 60755	gene/protein HDAC9 increases_expression of gene/protein VEGFA tested via knockdown experiments of HDAC9/HDAC10
Drugbank entries	Show/Hide entries for HDAC9 or VEGFA
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00112	Bevacizumab not specified VEGFA
Drugbank DB01017	Minocycline inhibitor VEGFA
Drugbank DB01120	Gliclazide other/unknown VEGFA
Drugbank DB01136	Carvedilol other VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA
Drugbank DB06779	Dalteparin inhibitor VEGFA
Drugbank DB01270	Ranibizumab not specified VEGFA
Drugbank DB03088	Pyroglutamic Acid not specified VEGFA
Drugbank DB03754	Tris(Hydroxymethyl)Aminomethane not specified VEGFA

Comment	In HDAC10 (class IIb HDAC) KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased VEGF expression.
Formal Description Interaction-ID: 60756	gene/protein HDAC9 increases_activity of process homologous recombination tested via knockdown experiments of HDAC9/HDAC10
Drugbank entries	Show/Hide entries for HDAC9
Drugbank DB00313	Valproic Acid inhibitor HDAC9

Comment	In HDAC10 (class IIb HDAC) KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased VEGF expression.
Formal Description Interaction-ID: 60757	gene/protein HDAC10 increases_activity of process homologous recombination tested via knockdown experiments of HDAC9/HDAC10

Comment	In HDAC10 (class IIb HDAC) KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased VEGF expression.
Formal Description Interaction-ID: 60759	gene/protein HDAC10 affects_activity of process cellular response to DNA damage stimulus tested via knockdown experiments of HDAC9/HDAC10

Comment	In HDAC10 (class IIb HDAC) KD of HDAC9/10 inhibited homologous recombination and increased sensitivity to DNA damage and decreased VEGF expression.
Formal Description Interaction-ID: 60760	gene/protein HDAC9 affects_activity of process cellular response to DNA damage stimulus tested via knockdown experiments of HDAC9/HDAC10
Drugbank entries	Show/Hide entries for HDAC9
Drugbank DB00313	Valproic Acid inhibitor HDAC9

Comment	HDAC11 (class IV HDAC) is associated with HDAC6. It is elevated in breast, renal, and liver cancer. KD induced apoptosis in colon, prostate, breast, and ovarian cancer cell lines.
Formal Description Interaction-ID: 60763	disease Breast cancer increases_expression of gene/protein HDAC11

Comment	HDAC11 (class IV HDAC) is associated with HDAC6. It is elevated in breast, renal, and liver cancer. KD induced apoptosis in colon, prostate, breast, and ovarian cancer cell lines.
Formal Description Interaction-ID: 60764	disease Hepatocellular carcinoma increases_expression of gene/protein HDAC11

Comment	HDAC11 (class IV HDAC) is associated with HDAC6. It is elevated in breast, renal, and liver cancer. KD induced apoptosis in colon, prostate, breast, and ovarian cancer cell lines.
Formal Description Interaction-ID: 60765	disease Renal cell carcinoma increases_expression of gene/protein HDAC11

Comment	HDAC11 (class IV HDAC) is associated with HDAC6. It is elevated in breast, renal, and liver cancer. KD induced apoptosis in colon, prostate, breast, and ovarian cancer cell lines.
Formal Description Interaction-ID: 60766	gene/protein HDAC11 decreases_activity of process apoptotic process in colon, prostate, breast, and ovarian cancer cell lines; tested via knockdown experiment

Comment	HDAC1 (class I HDAC) is associated with HDAC2, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, BCL6, p53, AR, ER, and Rb/E2F1. It is elevated in gastric, breast, colorectal cancer, HL (Hodgkin lymphoma), lung, and liver cancer. KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, breast, and osteosarcoma cancer cells and increased survival of mice with overt PML-RAR alpha-mediated APL; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO (knockout) induced genomic instability and arrest and reduced survival of transformed cells in vivo.
Formal Description Interaction-ID: 60826	gene/protein HDAC1 interacts (colocalizes) with complex/PPI CoREST complex via RCOR1/COREST
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 and HDAC2 (class I HDACs) are associated via RbAp46/RBBP7 with NURD complex and SIN3 complex (cited information, compare fig.2 of paper).
Formal Description Interaction-ID: 60827	gene/protein HDAC1 interacts (colocalizes) with gene/protein RBBP7
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 and HDAC2 (class I HDACs) are associated via RbAp46/RBBP7 with NURD complex and SIN3 complex (cited information, compare fig.2 of paper).
Formal Description Interaction-ID: 60828	gene/protein HDAC2 interacts (colocalizes) with gene/protein RBBP7
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC1 and HDAC2 (class I HDACs) are associated via RbAp46/RBBP7 with NURD complex and SIN3 complex (cited information, compare fig.2 of paper).
Formal Description Interaction-ID: 60829	gene/protein HDAC1 interacts (colocalizes) with gene/protein RBBP4
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	HDAC1 and HDAC2 (class I HDACs) are associated via RbAp46/RBBP7 with NURD complex and SIN3 complex (cited information, compare fig.2 of paper).
Formal Description Interaction-ID: 60830	gene/protein HDAC2 interacts (colocalizes) with gene/protein RBBP4
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC2 (class I HDAC) is associated with HDAC1, CoREST, NuRD, Sin3, AML1-ETO, PML, PLZF, and Bcl6. It is elevated in gastric, prostate, colorectal cancer, HL (Hodgkin lymphoma), and CTCL (cutaneous T cell lymphoma). KD (knockdown) induced growth arrest, decreased viability, and increased apoptosis in colon, and breast cancer cells and induced apoptosis and decreased lung cancer in vivo; HDAC1 KO/HDAC2 KD induced growth arrest in fibroblasts; KO induced genomic instability and arrest and reduced survival of transformed cells in vivo; KD induced apoptosis and decreased lung cancer in vivo.
Formal Description Interaction-ID: 60831	gene/protein HDAC2 interacts (colocalizes) with complex/PPI CoREST complex via RCOR1/COREST
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	HDAC3 (class I HDAC) is associated with NCoR complex via NCoR1 (cited information in fig.2 of paper).
Formal Description Interaction-ID: 60832	gene/protein HDAC3 interacts (colocalizes) with gene/protein NCOR1
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	HDAC3 (class I HDAC) is associated with NCoR complex via NCoR1 (cited information in fig.2 of paper).
Formal Description Interaction-ID: 60833	gene/protein HDAC3 interacts (colocalizes) with complex/PPI NCOR complex via NCOR1
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Apicidin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60834	drug/chemical compound Apicidin decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity of HDACi (HDAC inhibitor) Apicidin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60835	drug/chemical compound Apicidin decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Apicidin for HDACs and associated protein complexes.
Formal Description Interaction-ID: 60836	drug/chemical compound Apicidin decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Apicidin for HDACs and associated protein complexes.
Formal Description Interaction-ID: 60838	drug/chemical compound Apicidin decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Apicidin for HDACs and associated protein complexes.
Formal Description Interaction-ID: 60839	drug/chemical compound Apicidin decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Apicidin for HDACs and associated protein complexes.
Formal Description Interaction-ID: 60840	drug/chemical compound Apicidin decreases_activity of complex/PPI SIN3 complex

Comment	Specificity of HDACi (HDAC inhibitor) Apicidin for HDACs and associated protein complexes.
Formal Description Interaction-ID: 60841	drug/chemical compound Apicidin decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60844	drug/chemical compound Belinostat decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60845	drug/chemical compound Belinostat decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60846	drug/chemical compound Belinostat decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60847	drug/chemical compound Belinostat decreases_activity of gene/protein HDAC6
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60848	drug/chemical compound Belinostat decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60850	drug/chemical compound Belinostat decreases_activity of complex/PPI SIN3 complex

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60851	drug/chemical compound Belinostat decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Belinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60852	drug/chemical compound Belinostat decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Entinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60911	drug/chemical compound Entinostat decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity o f HDACi (HDAC inhibitor) Entinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60912	drug/chemical compound Entinostat decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Entinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60913	drug/chemical compound Entinostat decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Entinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60914	drug/chemical compound Entinostat decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Entinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60916	drug/chemical compound Entinostat decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Entinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60917	drug/chemical compound Entinostat decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Panobinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60920	drug/chemical compound Panobinostat decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity o f HDACi (HDAC inhibitor) Panobinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60921	drug/chemical compound Panobinostat decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Panobinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60922	drug/chemical compound Panobinostat decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Panobinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60923	drug/chemical compound Panobinostat decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Panobinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60924	drug/chemical compound Panobinostat decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Panobinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60925	drug/chemical compound Panobinostat decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Mocetinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60951	drug/chemical compound Mocetinostat decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity o f HDACi (HDAC inhibitor) Mocetinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60952	drug/chemical compound Mocetinostat decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Mocetinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60953	drug/chemical compound Mocetinostat decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Mocetinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60954	drug/chemical compound Mocetinostat decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Mocetinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60955	drug/chemical compound Mocetinostat decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Mocetinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60956	drug/chemical compound Mocetinostat decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Panobinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60957	drug/chemical compound Panobinostat decreases_activity of complex/PPI SIN3 complex

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60958	drug/chemical compound Abexinostat decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60959	drug/chemical compound Abexinostat decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60960	drug/chemical compound Abexinostat decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60961	drug/chemical compound Abexinostat decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60962	drug/chemical compound Abexinostat decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60963	drug/chemical compound Abexinostat decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60964	drug/chemical compound Abexinostat decreases_activity of complex/PPI SIN3 complex

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60965	drug/chemical compound Abexinostat decreases_activity of gene/protein HDAC6
Drugbank entries	Show/Hide entries for HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	Specificity of HDACi (HDAC inhibitor) Abexinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60966	drug/chemical compound Abexinostat decreases_activity of gene/protein HDAC10

Comment	Specificity of HDACi (HDAC inhibitor) PCl-334051 for HDAC8.
Formal Description Interaction-ID: 60967	drug/chemical compound PCl-334051 decreases_activity of gene/protein HDAC8
Drugbank entries	Show/Hide entries for HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8
Drugbank DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacet ... not specified HDAC8
Drugbank DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'- ... not specified HDAC8
Drugbank DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE not specified HDAC8
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethy ... not specified HDAC8
Drugbank DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-T ... not specified HDAC8
Drugbank DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4, ... not specified HDAC8

Comment	Specificity of HDACi (HDAC inhibitor) Romidepsin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60968	drug/chemical compound Romidepsin decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity of HDACi (HDAC inhibitor) Romidepsin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60969	drug/chemical compound Romidepsin decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Romidepsin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60970	drug/chemical compound Romidepsin decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Romidepsin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60971	drug/chemical compound Romidepsin decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Romidepsin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60972	drug/chemical compound Romidepsin decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Romidepsin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60973	drug/chemical compound Romidepsin decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Romidepsin for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60974	drug/chemical compound Romidepsin decreases_activity of complex/PPI SIN3 complex

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60975	drug/chemical compound Vorinostat decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for Vorinostat or HDAC1
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60976	drug/chemical compound Vorinostat decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for Vorinostat or HDAC2
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60977	drug/chemical compound Vorinostat decreases_activity of gene/protein HDAC3
Drugbank entries	Show/Hide entries for Vorinostat or HDAC3
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC3

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60978	drug/chemical compound Vorinostat decreases_activity of complex/PPI CoREST complex
Drugbank entries	Show/Hide entries for Vorinostat
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60979	drug/chemical compound Vorinostat decreases_activity of complex/PPI NuRD complex
Drugbank entries	Show/Hide entries for Vorinostat
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60980	drug/chemical compound Vorinostat decreases_activity of complex/PPI NCOR complex
Drugbank entries	Show/Hide entries for Vorinostat
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60981	drug/chemical compound Vorinostat decreases_activity of complex/PPI SIN3 complex
Drugbank entries	Show/Hide entries for Vorinostat
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1

Comment	Specificity of HDACi (HDAC inhibitor) Vorinostat for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60982	drug/chemical compound Vorinostat decreases_activity of gene/protein HDAC6
Drugbank entries	Show/Hide entries for Vorinostat or HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC3
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat not specified HDAC8
Drugbank DB02546	Vorinostat not specified acuC1
Drugbank DB02546	Vorinostat inhibitor HDAC6
Drugbank DB02546	Vorinostat inhibitor HDAC6

Comment	Specificity of HDACi (HDAC inhibitor) Trichostatin A for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60983	drug/chemical compound Trichostatin A decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity of HDACi (HDAC inhibitor) Trichostatin A for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60984	drug/chemical compound Trichostatin A decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for HDAC2
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Trichostatin A for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60985	drug/chemical compound Trichostatin A decreases_activity of complex/PPI CoREST complex

Comment	Specificity of HDACi (HDAC inhibitor) Trichostatin A for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60986	drug/chemical compound Trichostatin A decreases_activity of complex/PPI NuRD complex

Comment	Specificity of HDACi (HDAC inhibitor) Trichostatin A for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60987	drug/chemical compound Trichostatin A decreases_activity of complex/PPI NCOR complex

Comment	Specificity of HDACi (HDAC inhibitor) Trichostatin A for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60988	drug/chemical compound Trichostatin A decreases_activity of complex/PPI SIN3 complex

Comment	Specificity of HDACi (HDAC inhibitor) Valproic acid for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60989	drug/chemical compound Valproic acid decreases_activity of gene/protein HDAC1
Drugbank entries	Show/Hide entries for Valproic acid or HDAC1
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB
Drugbank DB02546	Vorinostat inhibitor HDAC1
Drugbank DB02546	Vorinostat inhibitor HDAC1

Comment	Specificity of HDACi (HDAC inhibitor) Valproic acid for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60990	drug/chemical compound Valproic acid decreases_activity of gene/protein HDAC2
Drugbank entries	Show/Hide entries for Valproic acid or HDAC2
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB
Drugbank DB00227	Lovastatin other HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2
Drugbank DB02546	Vorinostat inhibitor HDAC2

Comment	Specificity of HDACi (HDAC inhibitor) Valproic acid for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60991	drug/chemical compound Valproic acid decreases_activity of complex/PPI CoREST complex
Drugbank entries	Show/Hide entries for Valproic acid
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB

Comment	Specificity of HDACi (HDAC inhibitor) Valproic acid for HDAC and its associated protein complex.
Formal Description Interaction-ID: 60992	drug/chemical compound Valproic acid decreases_activity of complex/PPI NuRD complex
Drugbank entries	Show/Hide entries for Valproic acid
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB