General Information:

Id: 627 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0001279 spinal cord
article
Reference: Tolosa L et al.(2008) Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase. J. Neurochem. 105: 1080-1090 [PMID: 18182045]

Interaction Information:

Comment VEGF stimulation induces an increase in the phosphorylation of both Akt and ERK, with a maximal activation of both kinases after 12 h of exposure.
Formal Description
Interaction-ID: 3330

gene/protein

VEGFA

increases_activity of

gene/protein

AKT1

in spinal cord motoneurons
Drugbank entries Show/Hide entries for VEGFA or AKT1
Comment VEGF stimulation induces an increase in the phosphorylation of both Akt and ERK, with a maximal activation of both kinases after 12 h of exposure.
Formal Description
Interaction-ID: 3331

gene/protein

VEGFA

increases_phosphorylation of

gene/protein

AKT1

in spinal cord motoneurons
Drugbank entries Show/Hide entries for VEGFA or AKT1