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Field	Query

	Field	Term

General Information:

Id:	6,270
Diseases:	Glioblastoma
Organism:	Mus musculus
Publication type:	article
Reference:	Camphausen K et al.(2005) Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid Int. J. Cancer 114: 380-386 [PMID: 15578701]

Interaction Information:

Comment	Valproic acid (VA) administration to mice resulted in a clearly detectable level of histone hyperacetylation in U251 xenografts. Irradiation of U251 tumors in mice treated with VA resulted in an increase in radiation-induced tumor growth delay. Valproic acid enhanced the radiosensitivity of both SF539 and U251 cell lines in vitro and U251 xenografts in vivo, which correlated with the induction of histone hyperacetylation.
Formal Description Interaction-ID: 58622	drug/chemical compound Valproic acid increases_activity of phenotype increased cellular sensitivity to X-ray irradiation
Drugbank entries	Show/Hide entries for Valproic acid
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB

Comment	Valproic acid (VA) administration to mice resulted in a clearly detectable level of histone hyperacetylation in U251 xenografts. Irradiation of U251 tumors in mice treated with VA resulted in an increase in radiation-induced tumor growth delay. Valproic acid enhanced the radiosensitivity of both SF539 and U251 cell lines in vitro and U251 xenografts in vivo, which correlated with the induction of histone hyperacetylation.
Formal Description Interaction-ID: 58623	drug/chemical compound Valproic acid increases_activity of phenotype decreased tumor growth/size
Drugbank entries	Show/Hide entries for Valproic acid
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB

Comment	Histone hyperacetylation served as an indicator of HDAC inhibition. Valproic acid (VA) administration to mice resulted in a clearly detectable level of histone hyperacetylation in U251 xenografts. Irradiation of U251 tumors in mice treated with VA resulted in an increase in radiation-induced tumor growth delay. Valproic acid enhanced the radiosensitivity of both SF539 and U251 cell lines in vitro and U251 xenografts in vivo, which correlated with the induction of histone hyperacetylation.
Formal Description Interaction-ID: 58624	drug/chemical compound Valproic acid decreases_activity of gene/protein HDAC
Drugbank entries	Show/Hide entries for Valproic acid
Drugbank DB00313	Valproic Acid inhibitor ABAT
Drugbank DB00313	Valproic Acid inhibitor HDAC9
Drugbank DB00313	Valproic Acid inhibitor ACADSB

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