CIDeRplusGeneral Information:
| Id: | 6,260 (click here to show other Interactions for entry) |
| Diseases: |
Glioblastoma
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| Homo sapiens | |
| article | |
| Reference: | Camphausen K et al.(2005) Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid Int. J. Cancer 114: 380-386 [PMID: 15578701] |
Interaction Information:
| Comment | Valproic acid (VA) is a well-tolerated drug used to treat seizure disorders and has recently been shown to inhibit histone deacetylase (HDAC). The human glioma cell lines SF539 and U251 were used in this study. Histone hyperacetylation served as an indicator of HDAC inhibition. Irradiation at the time of maximum VA-induced histone hyperacetylation resulted in significant increases in the radiosensitivity of both SF539 and U251 cells. The radiosensitization was accompanied by a prolonged expression of gammaH2AX. As an initial investigation into the mechanism responsible for valproic acid-mediated radiosensitization, immunoblot analysis of phosphorylated histone H2AX (gammaH2AX) was used as an indicator of DNA damage. The maintenance of gammaH2AX levels suggests that the valproic acid-mediated radiosensitization involves the inhibition of the repair of DNA damage. |
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Formal Description Interaction-ID: 58621 |
drug/chemical compound decreases_activity of process |
| Drugbank entries | Show/Hide entries for Valproic acid |