CIDeRplusGeneral Information:
| Id: | 625 (click here to show other Interactions for entry) |
| Diseases: |
Epilepsy, temporal lobe
|
| Rattus norvegicus | |
| BTO:0000602 hippocampus; BTO:0000233 cerebral cortex | |
| article | |
| Reference: | Mazzuferi M et al.(2010) Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy Proc. Natl. Acad. Sci. U.S.A. 107: 3180-3185 [PMID: 20133704] |
Interaction Information:
| Comment | A significant reduction in the density of alpha1 subunit (GABRA1) and increase in alpha4 subunit (GABRA4) density were observed at the time of the first seizure in after pilocarpine administration. |
|
Formal Description Interaction-ID: 3317 |
drug/chemical compound decreases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or GABRA1 |