General Information:

Id: 6,206 (click here to show other Interactions for entry)
Diseases: Burkitt lymphoma - [OMIM]
Cancer
Homo sapiens
article/cited
Reference: Dong LH et al.(2013) Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma J Hematol Oncol 6: 53 [PMID: 23866964]

Interaction Information:

Comment The HDAC inhibitor VPA (valproic acid) overcomes MTOR inhibitor rapamycin resistance by inhibiting AKT via HDAC3 and potentiates autophagy through down-regulation of MTOR pathway.
Formal Description
Interaction-ID: 58407

drug/chemical compound

Valproic acid

increases_activity of

process

autophagy

through down-regulation of MTOR pathway.
Drugbank entries Show/Hide entries for Valproic acid