General Information:

Id: 6,166
Diseases: Neurological
Mus musculus
article/cited
Reference: Mouri A et al.(2012) MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation J. Neurosci. 32: 4562-4580 [PMID: 22457503]

Interaction Information:

Comment MAGE-D1 decreases SERT expression and serotonin uptake activity, as shown in Chinese hamster ovary (CHO) cells.
Formal Description
Interaction-ID: 57648

gene/protein

MAGED1

decreases_quantity of

gene/protein

SLC6A4

in CHO‚ÄďrSERT cells with MAGE-D1 overexpression
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Comment MAGE-D1 decreases SERT expression and serotonin uptake activity, as shown in Chinese hamster ovary (CHO) cells.
Formal Description
Interaction-ID: 57649

gene/protein

MAGED1

decreases_activity of

process

serotonin uptake

in CHO‚ÄďrSERT cells with MAGE-D1 overexpression
Comment MAGE-D1 interacts with SERT both in vitro (transfected CHO-cells) and in vivo (mouse brain).
Formal Description
Interaction-ID: 57650

gene/protein

MAGED1

interacts (colocalizes) with

gene/protein

SLC6A4

in vitro and in vivo
Drugbank entries Show/Hide entries for SLC6A4
Comment The MAGE-D1 knock-out and knockdown by small interfering RNA (siRNA) in the prefrontal cortex of mice showed depression-like behavior, such as a decrease in exploratory behavior in both the home cage and novel apparatus, a decrease in social interaction. The deficiency of MAGE-D1 induced not only behavioral but also neurological phenotypes of depression.
Formal Description
Interaction-ID: 57651

gene/protein

MAGED1

decreases_activity of

phenotype

abnormal depression-related behavior

Comment SERT ubiquitylation is regulated by MAGE-D1. MAGE-D1 binds to SERT and reduces serotonin reuptake activity and SERT protein levels as a result of an increase in SERT ubiquitylation. MAGE-D1 KO mice displayed an increase in SERT protein level without changes in mRNA expression via a decrease in its ubiquitylation in the prefrontal cortex.
Formal Description
Interaction-ID: 57652

gene/protein

MAGED1

increases_ubiquitination/sumoylation of

gene/protein

SLC6A4

Drugbank entries Show/Hide entries for SLC6A4
Comment SERT levels are elevated in the brains of depressive patients (cited information).
Formal Description
Interaction-ID: 57653

disease

Major depressive disorder

increases_quantity of

gene/protein

SLC6A4

Drugbank entries Show/Hide entries for SLC6A4
Comment The MAGE-D1 knock-out and knockdown by small interfering RNA (siRNA) in the prefrontal cortex of mice showed depression-like behavior, such as a decrease in exploratory behavior in both the home cage and novel apparatus, a decrease in social interaction. The deficiency of MAGE-D1 induced not only behavioral but also neurological phenotypes of depression.
Formal Description
Interaction-ID: 61047

gene/protein

MAGED1

affects_activity of

phenotype

abnormal depression-related behavior

Comment The serotonin transporter SERT is ubiquitylated and degraded by proteasome and MAGE-D1 controls this ubiquitylation process.
Formal Description
Interaction-ID: 61055

gene/protein

SLC6A4

increases_transport of

drug/chemical compound

Serotonin

Drugbank entries Show/Hide entries for SLC6A4