CIDeRplusGeneral Information:
| Id: | 598 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mus musculus | |
| male | |
| article | |
| Reference: | Cederroth CR et al.(2008) Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism Diabetes 57: 1176-1185 [PMID: 18420492] |
Interaction Information:
| Comment | Exposure to high-phytoestrogen soy-based diet significantly decreased weight, overall fat and adipose tissue weight of adult male mice. |
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Formal Description Interaction-ID: 3153 |
environment high-phytoestrogen soy-based diet decreases_quantity of tissue/cell line |
| Comment | Ghrelin levels were unchanged, whereas leptin levels were significantly lower in the serum of high-phytoestrogen-fed mice, presumably reflecting the decrease in adipose tissue mass. |
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Formal Description Interaction-ID: 3185 |
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| Comment | Ghrelin levels were unchanged, whereas leptin levels were significantly lower in the serum of high-phytoestrogen-fed mice, presumably reflecting the decrease in adipose tissue mass. |
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Formal Description Interaction-ID: 3186 |
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| Comment | Cholesterol levels were reduced in the serum of high-phytoestrogen-fed mice, but triglyceride and free fatty acid levels did not differ. |
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Formal Description Interaction-ID: 3188 |
environment high-phytoestrogen soy-based diet NOT affects_quantity of drug/chemical compound |
| Comment | Cholesterol levels were reduced in the serum of high-phytoestrogen-fed mice, but triglyceride and free fatty acid levels did not differ. |
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Formal Description Interaction-ID: 3189 |
environment high-phytoestrogen soy-based diet NOT affects_quantity of drug/chemical compound |
| Comment | Triglycerides and cholesterol were strongly reduced in white adipose tissue and, to a lesser extent, in muscles of high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 3191 |
environment high-phytoestrogen soy-based diet decreases_quantity of drug/chemical compound |
| Comment | In the liver of high-phytoestrogen-fed mice triglycerides were reduced while cholesterol levels remained unchanged. |
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Formal Description Interaction-ID: 3192 |
environment high-phytoestrogen soy-based diet NOT affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | In comparison with low-phytoestrogen-fed mice, high-phytoestrogen-fed mice displayed higher phosphorylation of AMPK at Thr172 and similar increases in the phosphorylation of its downstream target ACC at Ser79 in skeletal muscle, liver, and white adipose tissue. |
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Formal Description Interaction-ID: 3195 |
environment high-phytoestrogen soy-based diet increases_phosphorylation of complex/PPI AMPK |
| Comment | In comparison with low-phytoestrogen-fed mice, high-phytoestrogen-fed mice displayed higher phosphorylation of AMPK at Thr172 and similar increases in the phosphorylation of its downstream target ACC at Ser79 in skeletal muscle, liver, and white adipose tissue. |
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Formal Description Interaction-ID: 3196 |
environment high-phytoestrogen soy-based diet increases_phosphorylation of gene/protein |
| Drugbank entries | Show/Hide entries for ACACA |
| Comment | The AMP:ATP ratio was unchanged between skeletal muscles of high- and low-phytoestrogen-fed mice, suggesting that the activation of AMPK mediated by dietary soy does not involve global changes in AMP, ADP, or ATP. |
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Formal Description Interaction-ID: 3197 |
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| Comment | The expression of genes essential for mitochondrial biogenesis and peroxisomal fatty acid oxidation, respectively peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1 alpha) and peroxisome proliferator-activated receptor alpha (PPAR alpha), were upregulated in white adipose tissue, skeletal muscle, and liver of high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 3199 |
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| Comment | The expression of genes essential for mitochondrial biogenesis and peroxisomal fatty acid oxidation, respectively peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1 alpha) and peroxisome proliferator-activated receptor alpha (PPAR alpha), were upregulated in white adipose tissue, skeletal muscle, and liver of high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 3201 |
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| Drugbank entries | Show/Hide entries for PPARA |
| Comment | Acyl-CoA oxidase, a downstream target of PPAR-alpha, was upregulated in white adipose tissue of high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 3204 |
environment high-phytoestrogen soy-based diet increases_expression of gene/protein ACOX |
| Comment | In high-phytoestrogen-fed mice the expression of genes involved in mitochondrial metabolism was increased, the increase was higher in white adipose tissue compared with muscle and liver. Dietary soy probably promotes fatty acid oxidation and leanness by activating AMPK and improving PGC 1 alpha-related mitochondrial metabolism preferentially in white adipose tissue. |
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Formal Description Interaction-ID: 3205 |
environment high-phytoestrogen soy-based diet increases_activity of process mitochondrial metabolic process |
| Comment | In high-phytoestrogen-fed mice the expression of Tfam was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3206 |
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| Comment | In high-phytoestrogen-fed mice the expression of ERR-alpha was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3207 |
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| Drugbank entries | Show/Hide entries for ESRRA |
| Comment | In high-phytoestrogen-fed mice the expression of PGC1b was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3212 |
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| Comment | In high-phytoestrogen-fed mice the expression of catalase was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3213 |
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| Drugbank entries | Show/Hide entries for CAT |
| Comment | In high-phytoestrogen-fed mice the expression of SOD1 was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3214 |
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| Drugbank entries | Show/Hide entries for SOD1 |
| Comment | In high-phytoestrogen-fed mice the expression of SOD2 was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3215 |
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| Drugbank entries | Show/Hide entries for SOD2 |
| Comment | In high-phytoestrogen-fed mice the expression of Gpx1 was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3216 |
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| Drugbank entries | Show/Hide entries for GPX1 |
| Comment | In high-phytoestrogen-fed mice the expression of ANT was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3217 |
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| Drugbank entries | Show/Hide entries for SLC25A4 |
| Comment | In high-phytoestrogen-fed mice the expression of ATP5j was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3218 |
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| Comment | In high-phytoestrogen-fed mice the expression of ATP synb was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3219 |
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| Comment | In high-phytoestrogen-fed mice the expression of COX II was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3220 |
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| Drugbank entries | Show/Hide entries for MT-CO2 |
| Comment | In high-phytoestrogen-fed mice the expression of COX III was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3221 |
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| Drugbank entries | Show/Hide entries for MT-CO3 |
| Comment | In high-phytoestrogen-fed mice the expression of COX IV was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3223 |
environment high-phytoestrogen soy-based diet increases_expression of gene/protein COX4 |
| Comment | In high-phytoestrogen-fed mice the expression of COX 5b was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3224 |
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| Drugbank entries | Show/Hide entries for COX5B |
| Comment | In high-phytoestrogen-fed mice the expression of COX 6a was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3225 |
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| Comment | In high-phytoestrogen-fed mice the expression of Cytc was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3227 |
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| Drugbank entries | Show/Hide entries for CYCS |
| Comment | In high-phytoestrogen-fed mice the expression of Ndnfb5 was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3228 |
environment high-phytoestrogen soy-based diet increases_expression of gene/protein NDNFB5 |
| Comment | In high-phytoestrogen-fed mice the expression of UCP3 was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3229 |
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| Comment | In high-phytoestrogen-fed mice the expression of ACoAx was increased in white adipose tissue. |
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Formal Description Interaction-ID: 3231 |
environment high-phytoestrogen soy-based diet increases_expression of gene/protein ACOX |
| Comment | Although glycemia was comparable, basal serum insulin levels were significantly lower in high-phytoestrogen-fed mice, suggesting that dietary soy could affect total pancreatic insulin content and/or insulin secretion. |
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Formal Description Interaction-ID: 3233 |
environment high-phytoestrogen soy-based diet decreases_quantity of complex/PPI Insulin |
| Comment | The release of insulin in response to a basal glucose concentration was lower in high-phytoestrogen-fed mice compared to low-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 3238 |
environment high-phytoestrogen soy-based diet affects_activity of process |
| Comment | In high-phytoestrogen-fed mice the glucose uptake and insulin sensitivity are increased. |
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Formal Description Interaction-ID: 3239 |
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| Comment | Phosphorylation of IRS1 (Y632) in high-phytoestrogen-fed mice was lower than in low-phytoestrogen-fed mice in basal conditions, probably reflecting the lower serum insulin levels in high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 3240 |
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| Drugbank entries | Show/Hide entries for IRS1 |
| Comment | Upon insulin stimulation, phosphorylation of IRS1 (Y632) was similar in low- and high-phytoestrogen-fed mice, but IRS1 (S636/S639), mTOR (S2448), and S6K1 (T389) levels were significantly lower in high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 3241 |
environment high-phytoestrogen soy-based diet affects_phosphorylation of gene/protein |
| Drugbank entries | Show/Hide entries for IRS1 |
| Comment | Phosphorylation of Akt (T308/S473) was significantly higher in high-phytoestrogen-fed mice in the insulin-stimulated state. |
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Formal Description Interaction-ID: 3242 |
environment high-phytoestrogen soy-based diet affects_phosphorylation of gene/protein |
| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | In peripheral tissues of soy-fed mice, especially in white adipose tissue, phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase was increased, and expression of genes implicated in peroxisomal fatty acid oxidation and mitochondrial biogenesis was upregulated. Soy-fed mice also showed reduced serum insulin levels and pancreatic insulin content and improved insulin sensitivity due to increased glucose uptake into skeletal muscle. Thus, mice fed with a soy-rich diet have improved adipose and glucose metabolism. |
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Formal Description Interaction-ID: 3244 |
environment high-phytoestrogen soy-based diet increases_activity of process |
| Comment | Triglycerides and cholesterol were strongly reduced in white adipose tissue and, to a lesser extent, in muscles of high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 12853 |
environment high-phytoestrogen soy-based diet decreases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | In the liver of high-phytoestrogen-fed mice triglycerides were reduced while cholesterol levels remained unchanged. |
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Formal Description Interaction-ID: 12854 |
environment high-phytoestrogen soy-based diet decreases_quantity of drug/chemical compound |
| Comment | In high-phytoestrogen-fed mice the glucose uptake and insulin sensitivity are increased. |
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Formal Description Interaction-ID: 12908 |
environment high-phytoestrogen soy-based diet increases_activity of phenotype |
| Comment | Upon insulin stimulation, phosphorylation of IRS1 (Y632) was similar in low- and high-phytoestrogen-fed mice, but IRS1 (S636/S639), mTOR (S2448), and S6K1 (T389) levels were significantly lower in high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 12911 |
environment high-phytoestrogen soy-based diet affects_phosphorylation of gene/protein |
| Drugbank entries | Show/Hide entries for MTOR |
| Comment | Upon insulin stimulation, phosphorylation of IRS1 (Y632) was similar in low- and high-phytoestrogen-fed mice, but IRS1 (S636/S639), mTOR (S2448), and S6K1 (T389) levels were significantly lower in high-phytoestrogen-fed mice. |
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Formal Description Interaction-ID: 12912 |
environment high-phytoestrogen soy-based diet affects_phosphorylation of gene/protein |
| Comment | In peripheral tissues of soy-fed mice, especially in white adipose tissue, phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase was increased, and expression of genes implicated in peroxisomal fatty acid oxidation and mitochondrial biogenesis was upregulated. Soy-fed mice also showed reduced serum insulin levels and pancreatic insulin content and improved insulin sensitivity due to increased glucose uptake into skeletal muscle. Thus, mice fed with a soy-rich diet have improved adipose and glucose metabolism. |
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Formal Description Interaction-ID: 12916 |
environment high-phytoestrogen soy-based diet increases_activity of process |
| Comment | In peripheral tissues of soy-fed mice, especially in white adipose tissue, phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase was increased, and expression of genes implicated in peroxisomal fatty acid oxidation and mitochondrial biogenesis was upregulated. Soy-fed mice also showed reduced serum insulin levels and pancreatic insulin content and improved insulin sensitivity due to increased glucose uptake into skeletal muscle. Thus, mice fed with a soy-rich diet have improved adipose and glucose metabolism. |
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Formal Description Interaction-ID: 12921 |
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| Comment | The AMP:ATP ratio was unchanged between skeletal muscles of high- and low-phytoestrogen-fed mice, suggesting that the activation of AMPK mediated by dietary soy does not involve global changes in AMP, ADP, or ATP. |
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Formal Description Interaction-ID: 46078 |
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