CIDeRplusGeneral Information:
| Id: | 591 (click here to show other Interactions for entry) |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Homo sapiens | |
| BTO:0004488 NSC-34 cell | |
| article | |
| Reference: | Ferri A et al.(2006) Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials Proc. Natl. Acad. Sci. U.S.A. 103 [PMID: 16945901] |
Interaction Information:
| Comment | MutSOD1s themselves may contribute to creating a prooxidant environment, because expression of many of the mutSOD1s was found to shift the GSH/GSSG ratio toward the oxidized form in mitochondria of motoneuronal cells, irrespective of the basal level. |
|
Formal Description Interaction-ID: 13793 |
gene/protein mutant increases_activity of process |