General Information:

Id: 568
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0004102 cerebral cortical neuron
article
Reference: Manser C et al.(2008) Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport. FEBS Lett. 582: 2303-2308 [PMID: 18519042]

Interaction Information:

Comment Glutamate induces caspase-mediated cleavage and activation of PKN1 in cultured cortical neurons.
Formal Description
Interaction-ID: 2961

drug/chemical compound

Glutamate

increases_activity of

gene/protein

CASP3

in cortical neurons
Drugbank entries Show/Hide entries for CASP3
Comment Glutamate induces caspase-mediated cleavage and activation of PKN1 in cultured cortical neurons.
Formal Description
Interaction-ID: 2964

gene/protein

CASP3

increases_activity of

gene/protein

PKN1

in cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for CASP3
Comment A cleaved form of PKN1, PKN1(561-942) but not wild-type PKN1 disrupts neurofilament organisation and axonal transport. Co-transfection of PKN1wt had no significant effect on neurofilament transport, co-transfection of PKN1(561-942) induced a marked inhibition in the movement of neurofilaments.
Formal Description
Interaction-ID: 2974

protein modification

PKN1-mod

decreases_activity of

process

neurofilament cytoskeleton organization

in cortical neurons
Comment A cleaved form of PKN1, PKN1(561-942) but not wild-type PKN1 disrupts neurofilament organisation and axonal transport. Co-transfection of PKN1wt had no significant effect on neurofilament transport, co-transfection of PKN1(561-942) induced a marked inhibition in the movement of neurofilaments.
Formal Description
Interaction-ID: 2976

protein modification

PKN1-mod

decreases_activity of

process

axon cargo transport

in cortical neurons
Comment Glutamate induces caspase-mediated cleavage and activation of PKN1 in cultured cortical neurons.
Formal Description
Interaction-ID: 15825

gene/protein

CASP3

increases_quantity of

protein modification

PKN1-mod

in cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for CASP3