General Information:

Id: 565
Diseases: Status epilepticus
Rattus norvegicus
Wistar
article
Reference: Santos IM et al.(2010) Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain Pharmacol. Biochem. Behav. 95: 88-91 [PMID: 20026167]

Interaction Information:

Comment The pilocarpine group showed a reduction in delta-ALA-D and Na(+), K(+)-ATPase activities after seizures.
Formal Description
Interaction-ID: 2949

drug/chemical compound

Pilocarpine

decreases_activity of

gene/protein

ATP1A1

in pilocarpine model
Drugbank entries Show/Hide entries for Pilocarpine or ATP1A1
Comment The pilocarpine group showed a reduction in delta-ALA-D and Na(+), K(+)-ATPase activities after seizures.
Formal Description
Interaction-ID: 2950

drug/chemical compound

Pilocarpine

decreases_activity of

gene/protein

ALAD

in pilocarpine model
Drugbank entries Show/Hide entries for Pilocarpine or ALAD
Comment Lipoic acid plus pilocarpine abolished the appearance of seizures and reversed the decreased in delta-ALA-D and Na(+), K(+)-ATPase activities produced by seizures, when compared to the pilocarpine seizing group.
Formal Description
Interaction-ID: 2951

drug/chemical compound

Lipoate

increases_activity of

gene/protein

ATP1A1

in pilocarpine model
Drugbank entries Show/Hide entries for ATP1A1
Comment Lipoic acid plus pilocarpine abolished the appearance of seizures and reversed the decreased in delta-ALA-D and Na(+), K(+)-ATPase activities produced by seizures, when compared to the pilocarpine seizing group.
Formal Description
Interaction-ID: 2952

drug/chemical compound

Lipoate

increases_activity of

gene/protein

ALAD

in pilocarpine model
Drugbank entries Show/Hide entries for ALAD