CIDeRplusGeneral Information:
| Id: | 5,473 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| article | |
| Reference: | Smith SB et al.(1999) Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development Mol. Cell. Biol. 19: 8272-8280 [PMID: 10567552] |
Interaction Information:
| Comment | Expression and reporter constructs were co-transfected into alpha (alphaTC1.6), beta (betaTC3 and HIT-T15 M2.2.2), and nonislet (NIH 3T3) cell lines. PAX4 represses transcription from the intact insulin and glucagon promoters. PAX4 represses transcription through its binding site, this effect may depend on the cellular context. |
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Formal Description Interaction-ID: 53306 |
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