General Information:

Id: 542
Diseases: Status epilepticus
Rattus norvegicus
Sprague-Dawley, neonatal
BTO:0002807 prefrontal cortex; BTO:0001311 corpus striatum
article
Reference: Lin TC et al.(2009) Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence Epilepsy Behav 14: 316-323 [PMID: 19126440]

Interaction Information:

Comment Rats previously subjected to lithium-pilocarpine induced neonatal status epilepticus exhibited enhanced behavioral sensitization to methamphetamine in adolescence.
Formal Description
Interaction-ID: 2738

disease

Status epilepticus

increases_activity of

process

response to amphetamine

in pilocarpine model
Comment Dopamine was decreased in prefrontal cortex and insignificantly changed in striatum by pilocarpine-induced neonatal status epilepticus.
Formal Description
Interaction-ID: 2741

disease

Status epilepticus

decreases_quantity of

drug/chemical compound

Dopamine

in pilocarpine model
Drugbank entries Show/Hide entries for
Comment Dopamine was increased in prefrontal cortex and in striatum after addition of methamphetamine to pilocarpine-treated cells.
Formal Description
Interaction-ID: 2742

drug/chemical compound

Metamfetamine

increases_quantity of

drug/chemical compound

Dopamine

in pilocarpine model
Drugbank entries Show/Hide entries for
Comment Glutamate levels were increased in both prefrontal cortex and striatum after addition of methamphetamine to pilocarpine-treated cells.
Formal Description
Interaction-ID: 2743

drug/chemical compound

Metamfetamine

increases_quantity of

drug/chemical compound

Glutamate

in pilocarpine model