General Information:

Id: 5,416
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Yadav VK et al.(2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum Cell 135: 825-837 [PMID: 19041748]

Interaction Information:

Comment Lrp5 inhibits expression of Tph1, the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum.
Formal Description
Interaction-ID: 52893

gene/protein

LRP5

decreases_expression of

gene/protein

TPH1

Drugbank entries Show/Hide entries for TPH1
Comment Decreasing serotonin blood levels normalizes bone formation and bone mass in Lrp5-deficient mice, and gut- but not osteoblast-specific Lrp5 inactivation decreases bone formation in a beta-Catenin-independent manner.
Formal Description
Interaction-ID: 52904

gene/protein

LRP5

affects_activity of

process

bone development

via serotonin
Comment Decreasing serotonin blood levels normalizes bone formation and bone mass in Lrp5-deficient mice, and gut- but not osteoblast-specific Lrp5 inactivation decreases bone formation in a beta-Catenin-independent manner.
Formal Description
Interaction-ID: 52905

gene/protein

LRP5

affects_activity of

phenotype

decreased bone mass

via serotonin
Comment Gut-specific activation of Lrp5, or inactivation of Tph1, increases bone mass and prevents ovariectomy-induced bone loss.
Formal Description
Interaction-ID: 52906

gene/protein

LRP5

increases_activity of

phenotype

increased bone mass

if LRP5 is activated in the gut
Comment Gut-specific activation of Lrp5, or inactivation of Tph1, increases bone mass and prevents ovariectomy-induced bone loss.
Formal Description
Interaction-ID: 52907

gene/protein

TPH1

affects_activity of

phenotype

increased bone mass

Drugbank entries Show/Hide entries for TPH1
Comment Serotonin acts on osteoblasts through the Htr1b receptor and CREB to inhibit their proliferation.
Formal Description
Interaction-ID: 52908

drug/chemical compound

Serotonin

increases_activity of

gene/protein

HTR1B

in osteoblasts
Drugbank entries Show/Hide entries for HTR1B
Comment Serotonin acts on osteoblasts through the Htr1b receptor and CREB to inhibit their proliferation.
Formal Description
Interaction-ID: 52909

drug/chemical compound

Serotonin

increases_activity of

gene/protein

CREB1

in osteoblasts
Drugbank entries Show/Hide entries for CREB1
Comment Serotonin acts on osteoblasts through the Htr1b receptor and CREB to inhibit their proliferation.
Formal Description
Interaction-ID: 52910

drug/chemical compound

Serotonin

decreases_activity of

process

osteoblast proliferation