CIDeRplusGeneral Information:
| Id: | 5,317 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| BTO:0001169 3T3-F442A cell | |
| article | |
| Reference: | Ye L et al.(2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis Cell 151: 96-110 [PMID: 23021218] |
Interaction Information:
| Comment | TRPV4 is a calcium-permeable ion channel that was first identified as an osmolality sensor. Since then, many physical and chemical stimuli have been shown to activate TRPV4, including heat, mechanical stress, anandamide, arachidonic acid, and its derivatives. Beta-adrenergic signaling is important for the induction of PGC1alpha and its thermogenic targets; when cells were exposed to norepinephrine, mRNA expression of Pgc1alpha and Ucp1 was robustly increased in the TRPV4 knockdown cells compared to controls. |
|
Formal Description Interaction-ID: 52228 |
drug/chemical compound increases_expression of gene/protein |