CIDeRplusGeneral Information:
| Id: | 5,172 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
Neurological |
| Mammalia | |
| review | |
| Reference: | Sokolov AN et al.(2013) Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior Neurosci Biobehav Rev 37: 2445-2453 [PMID: 23810791] |
Interaction Information:
| Comment | The effects of short-term versus long-term (two-week) oral administration of cocoa mass in large amounts (100 mg/100 g body weight) were compared in the rat elevated T-maze test, an animal model of anxiety. Short-term administration significantly abolished avoidance behavior during immediate test performance, suggesting a reduced fear conditioning. Long-term administration enhanced brain concentration of emotion-related neurotransmitter serotonin and its turnover. long-term intake of cocoa mass affects brain monoamine metabolism. |
|
Formal Description Interaction-ID: 50763 |
drug/chemical compound Cocoa increases_quantity of drug/chemical compound |